7NE1

Structure of the complex between Netrin-1 and its receptor Neogenin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Netrin-1	polymer	444	49600.8	1	UniProt (O95631) Pfam (PF00055) Pfam (PF00053) In PDB	Homo sapiens (Human)	Epididymis tissue protein Li 131P
2	B	Neogenin	polymer	354	39268.2	1	UniProt (Q7TQG5) Pfam (PF00041) In PDB	Mus musculus (House mouse)
3	G	1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose	branched		982.8	1	In PDB BIRD (PRD_900013)
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	A	NITRATE ION	non-polymer		62.0	3	Chemie (NO3)

Sequence modifications

A: 24 - 453 (UniProt: O95631)

PDB	External Database	Details
Glu 22	-	expression tag
Thr 23	-	expression tag
Gly 454	-	expression tag
Thr 455	-	expression tag
Lys 456	-	expression tag
Thr 457	-	expression tag
Glu 458	-	expression tag
Thr 459	-	expression tag
Ser 460	-	expression tag
Gln 461	-	expression tag
Val 462	-	expression tag
Ala 463	-	expression tag
Pro 464	-	expression tag
Ala 465	-	expression tag

B: 766 - 1107 (UniProt: Q7TQG5)

PDB	External Database	Details
Glu 763	-	expression tag
Thr 764	-	expression tag
Gly 765	-	expression tag
Gly 1108	-	expression tag
Thr 1109	-	expression tag
Lys 1110	-	expression tag
His 1111	-	expression tag
His 1112	-	expression tag
His 1113	-	expression tag
His 1114	-	expression tag
His 1115	-	expression tag
His 1116	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88869.0
Branched	Number of molecules	1
	Total formula weight	982.8
Non-Polymers*	Number of molecules	8
	Total formula weight	1110.9
All*	Total formula weight	90962.7

*Water molecules are not included.