7N94

LINE-1 endonuclease domain complex with DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	LINE-1 retrotransposable element ORF2 protein	polymer	238	27073.2	2	UniProt (O00370) Pfam (PF03372)	Homo sapiens (Human)	ORF2p
2	B, E (D, F)	DNA (5'-D(*GP*CP*TP*CP*CP*TP*TP*TP*TP*TP*AP*AP*GP*GP*GP*CP*TP*A)-3')	polymer	18	5497.6	2		Homo sapiens
3	C, F (E, G)	DNA (5'-D(*AP*GP*CP*CP*CP*TP*TP*AP*AP*AP*AP*AP*GP*GP*AP*GP*CP*T)-3')	polymer	18	5533.6	2		Homo sapiens

Sequence modifications

A, B: 1 - 238 (UniProt: O00370)

PDB	External Database	Details
Ile 15	Val 15	conflict
Ala 21	Pro 21	conflict
Ala 145	Asp 145	engineered mutation
Thr 152	Ile 152	conflict
Ala 175	Thr 175	conflict
Lys 226	Tyr 226	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	76208.8
All*	Total formula weight	76208.8

*Water molecules are not included.