7MQ9
Cryo-EM structure of the human SSU processome, state pre-A1*
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L0) | 5'ETS rRNA | polymer | 3617 | 1166881.9 | 1 | GenBank (1212788588) | Homo sapiens | |
| 2 | B (L1) | 18S rRNA | polymer | 1872 | 603757.5 | 1 | GenBank (151415227) | Homo sapiens | |
| 3 | C (L2) | U3 snoRNA | polymer | 217 | 70017.2 | 1 | GenBank (37551) | Homo sapiens | |
| 4 | D (L3) | 40S ribosomal protein S18 | polymer | 116 | 12672.0 | 1 | Pfam (PF00416) UniProt (by SIFTS) (P62269) | Homo sapiens (Human) | |
| 5 | E (L4) | 40S ribosomal protein S4 X isoform | polymer | 263 | 29654.9 | 1 | Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) UniProt (by SIFTS) (P62701) | Homo sapiens (Human) | |
| 6 | F (L5) | 40S ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (Human) | Small ribosomal subunit protein uS7 |
| 7 | G (L6) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (Human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 8 | H (L7) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (Human) | Small ribosomal subunit protein eS7 |
| 9 | I (L8) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (Human) | Small ribosomal subunit protein eS8 |
| 10 | J (L9) | 40S ribosomal protein S9 | polymer | 194 | 22641.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (Human) | Small ribosomal subunit protein uS4 |
| 11 | K (LA) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (Human) | Small ribosomal subunit protein eS12 |
| 12 | L (LC) | 40S ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (Human) | Small ribosomal subunit protein uS9 |
| 13 | M (LD) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (Human) | Small ribosomal subunit protein uS17 |
| 14 | N (LF) | 40S ribosomal protein S24 | polymer | 133 | 15463.3 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (Human) | Small ribosomal subunit protein eS24 |
| 15 | O (LG) | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (Human) | Small ribosomal subunit protein eS28 |
| 16 | P (LH) | WD repeat-containing protein 75 | polymer | 830 | 94609.6 | 1 | UniProt (Q8IWA0) Pfam (PF23869) Pfam (PF23769) | Homo sapiens (Human) | U3 small nucleolar RNA-associated protein 17 homolog |
| 17 | Q (LI) | Nucleolar protein 11 | polymer | 699 | 75231.9 | 1 | Pfam (PF08168) Pfam (PF20998) UniProt (by SIFTS) (Q9H8H0) | Homo sapiens (Human) | |
| 18 | R (LJ) | U3 small nucleolar RNA-associated protein 15 homolog | polymer | 518 | 58503.2 | 1 | UniProt (Q8TED0) Pfam (PF00400) Pfam (PF09384) | Homo sapiens (Human) | |
| 19 | S, T (LK, LL) | WD repeat-containing protein 43 | polymer | 677 | 74985.6 | 2 | UniProt (Q15061) Pfam (PF00400) Pfam (PF04003) | Homo sapiens (Human) | U3 small nucleolar RNA-associated protein 5 homolog |
| 20 | U (LN) | U3 small nucleolar RNA-associated protein 4 homolog | polymer | 686 | 76993.1 | 1 | UniProt (Q969X6) Pfam (PF00400) | Homo sapiens (Human) | Cirhin,UTP4 small subunit processome component |
| 21 | V (LO) | Periodic tryptophan protein 2 homolog | polymer | 919 | 102575.0 | 1 | UniProt (Q15269) Pfam (PF00400) Pfam (PF04003) | Homo sapiens (Human) | |
| 22 | W (LP) | U3 small nucleolar RNA-associated protein 6 homolog | polymer | 597 | 70297.9 | 1 | UniProt (Q9NYH9) Pfam (PF08640) Pfam (PF24892) | Homo sapiens (Human) | Hepatocellular carcinoma-associated antigen 66,Multiple hat domains protein |
| 23 | X (LQ) | WD repeat-containing protein 3 | polymer | 943 | 106248.0 | 1 | UniProt (Q9UNX4) Pfam (PF25173) Pfam (PF25172) Pfam (PF04003) | Homo sapiens (Human) | |
| 24 | Y (LS) | U3 small nucleolar RNA-associated protein 18 homolog | polymer | 556 | 62097.5 | 1 | UniProt (Q9Y5J1) Pfam (PF00400) | Homo sapiens (Human) | WD repeat-containing protein 50 |
| 25 | Z (LT) | WD repeat-containing protein 36 | polymer | 951 | 105443.0 | 1 | UniProt (Q8NI36) Pfam (PF25171) Pfam (PF25168) Pfam (PF04192) | Homo sapiens (Human) | T-cell activation WD repeat-containing protein,TA-WDRP |
| 26 | AA (LU) | DDB1- and CUL4-associated factor 13 | polymer | 445 | 51489.3 | 1 | UniProt (Q9NV06) Pfam (PF00400) Pfam (PF04158) | Homo sapiens (Human) | WD repeat and SOF domain-containing protein 1 |
| 27 | BA (LW) | WD repeat-containing protein 46 | polymer | 610 | 68189.2 | 1 | UniProt (O15213) Pfam (PF00400) Pfam (PF08149) | Homo sapiens (Human) | WD repeat-containing protein BING4 |
| 28 | CA (LZ) | U3 small nucleolar ribonucleoprotein protein IMP3 | polymer | 184 | 21889.2 | 1 | UniProt (Q9NV31) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (Human) | U3 snoRNP protein IMP3,BRMS2 |
| 29 | DA (NA) | U3 small nucleolar ribonucleoprotein protein MPP10 | polymer | 681 | 78988.8 | 1 | UniProt (O00566) Pfam (PF04006) | Homo sapiens (Human) | M phase phosphoprotein 10 |
| 30 | EA (NB) | Something about silencing protein 10 | polymer | 479 | 54652.0 | 1 | UniProt (Q9NQZ2) Pfam (PF04000) Pfam (PF09368) | Homo sapiens (Human) | Charged amino acid-rich leucine zipper 1,CRL1,Disrupter of silencing SAS10,UTP3 homolog |
| 31 | FA (ND) | Nucleolar protein 7 | polymer | 257 | 29483.5 | 1 | UniProt (Q9UMY1) Pfam (PF08157) | Homo sapiens (Human) | Nucleolar protein of 27 kDa |
| 32 | GA (NE) | Uncharacterized protein C1orf131 | polymer | 293 | 32673.4 | 1 | UniProt (Q8NDD1) Pfam (PF15375) | Homo sapiens (Human) | |
| 33 | HA (NF) | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (Human) | Small ribosomal subunit protein uS15 |
| 34 | IA (NG) | 40S ribosomal protein S14 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (Human) | Small ribosomal subunit protein uS11 |
| 35 | JA, SB (NJ, NK) | RNA cytidine acetyltransferase | polymer | 1025 | 115882.8 | 2 | UniProt (Q9H0A0) Pfam (PF08351) Pfam (PF05127) Pfam (PF13718) Pfam (PF13725) | Homo sapiens (Human) | 18S rRNA cytosine acetyltransferase,N-acetyltransferase 10,N-acetyltransferase-like protein,hALP |
| 36 | KA (NM) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (Human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 37 | LA (NN) | Protein AATF | polymer | 560 | 63224.9 | 1 | UniProt (Q9NY61) Pfam (PF13339) Pfam (PF08164) | Homo sapiens (Human) | Apoptosis-antagonizing transcription factor,Rb-binding protein Che-1 |
| 38 | MA (NO) | 40S ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (Human) | Small ribosomal subunit protein uS8 |
| 39 | NA (NQ) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (Human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 40 | OA (NR) | RRP12-like protein | polymer | 861 | 73292.8 | 1 | Homo sapiens (Human) | ||
| 41 | PA (NT) | Ubiquitin-40S ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (P62979) Pfam (PF00240) Pfam (PF01599) | Homo sapiens (Human) | Ubiquitin carboxyl extension protein 80 |
| 42 | QA (NU) | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (Human) | Small ribosomal subunit protein eS17 |
| 43 | RA (NW) | Nucleolar protein 10 | polymer | 688 | 80431.6 | 1 | UniProt (Q9BSC4) Pfam (PF23098) Pfam (PF23097) Pfam (PF08159) | Homo sapiens (Human) | |
| 44 | SA (SA) | Nucleolar protein 56 | polymer | 594 | 66160.1 | 1 | UniProt (O00567) Pfam (PF08156) Pfam (PF01798) | Homo sapiens (Human) | Nucleolar protein 5A |
| 45 | TA (SB) | Nucleolar protein 58 | polymer | 529 | 59686.3 | 1 | UniProt (Q9Y2X3) Pfam (PF08156) Pfam (PF01798) | Homo sapiens (Human) | Nucleolar protein 5 |
| 46 | UA, VA (SC, SD) | rRNA 2'-O-methyltransferase fibrillarin | polymer | 321 | 33843.3 | 2 | UniProt (P22087) Pfam (PF01269) | Homo sapiens (Human) | 34 kDa nucleolar scleroderma antigen,Histone-glutamine methyltransferase,U6 snRNA 2'-O-methyltransferase fibrillarin |
| 47 | WA, XA (SE, SF) | NHP2-like protein 1 | polymer | 128 | 14191.5 | 2 | UniProt (P55769) Pfam (PF01248) | Homo sapiens (Human) | High mobility group-like nuclear protein 2 homolog 1,OTK27,SNU13 homolog,hSNU13,U4/U6.U5 small nuclear ribonucleoprotein SNU13,U4/U6.U5 tri-snRNP 15.5 kDa protein |
| 48 | YA (SH) | RNA 3'-terminal phosphate cyclase-like protein | polymer | 373 | 40893.6 | 1 | UniProt (Q9Y2P8) Pfam (PF01137) Pfam (PF05189) | Homo sapiens (Human) | |
| 49 | ZA (SI) | Ribosome biogenesis protein BMS1 homolog | polymer | 1282 | 146045.0 | 1 | UniProt (Q14692) Pfam (PF08142) Pfam (PF04950) | Homo sapiens (Human) | Ribosome assembly protein BMS1 homolog |
| 50 | AB, VB (SK, SJ) | Ribosomal RNA small subunit methyltransferase NEP1 | polymer | 244 | 26757.1 | 2 | UniProt (Q92979) Pfam (PF03587) | Homo sapiens (Human) | 18S rRNA (pseudouridine(1248)-N1)-methyltransferase,18S rRNA Psi1248 methyltransferase,Nucleolar protein EMG1 homolog,Protein C2f,Ribosome biogenesis protein NEP1 |
| 51 | BB (SL) | rRNA-processing protein FCF1 homolog | polymer | 198 | 23416.7 | 1 | UniProt (Q9Y324) Pfam (PF04900) | Homo sapiens (Human) | |
| 52 | CB (SM) | U3 small nucleolar ribonucleoprotein protein IMP4 | polymer | 291 | 33818.7 | 1 | UniProt (Q96G21) Pfam (PF04427) | Homo sapiens (Human) | U3 snoRNP protein IMP4,Brix domain-containing protein 4 |
| 53 | DB (SQ) | Deoxynucleotidyltransferase terminal-interacting protein 2 | polymer | 756 | 84598.1 | 1 | UniProt (Q5QJE6) Pfam (PF08698) | Homo sapiens (Human) | Estrogen receptor-binding protein,LPTS-interacting protein 2,LPTS-RP2,Terminal deoxynucleotidyltransferase-interacting factor 2,TdIF2,TdT-interacting factor 2 |
| 54 | EB (SR) | 40S ribosomal protein S23 | polymer | 143 | 15844.7 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (Human) | Small ribosomal subunit protein uS12 |
| 55 | FB (SS) | U3 small nucleolar RNA-associated protein 14 homolog A | polymer | 771 | 88129.1 | 1 | UniProt (Q9BVJ6) Pfam (PF04615) | Homo sapiens (Human) | Antigen NY-CO-16,Serologically defined colon cancer antigen 16 |
| 56 | GB (SX) | Unassigned peptides | polymer | 177 | 15081.6 | 1 | Homo sapiens (Human) | ||
| 57 | HB (SY) | Probable U3 small nucleolar RNA-associated protein 11 | polymer | 253 | 30520.8 | 1 | UniProt (Q9Y3A2) Pfam (PF03998) | Homo sapiens (Human) | U3 snoRNA-associated protein 11,UTP11-like protein |
| 58 | IB (NH) | Nucleolar protein 6 | polymer | 1146 | 127748.6 | 1 | UniProt (Q9H6R4) Pfam (PF03813) Pfam (PF17403) Pfam (PF17404) Pfam (PF17405) Pfam (PF17406) Pfam (PF17407) | Homo sapiens (Human) | Nucleolar RNA-associated protein,Nrap |
| 59 | JB (SP) | Small subunit processome component 20 homolog | polymer | 2785 | 318813.3 | 1 | UniProt (O75691) Pfam (PF07539) Pfam (PF20416) Pfam (PF23099) | Homo sapiens (Human) | Down-regulated in metastasis protein,Novel nucleolar protein 73,NNP73,Protein Key-1A6 |
| 60 | KB (LR) | Transducin beta-like protein 3 | polymer | 808 | 89143.6 | 1 | UniProt (Q12788) Pfam (PF00400) Pfam (PF08625) | Homo sapiens (Human) | WD repeat-containing protein SAZD |
| 61 | LB (LM) | HEAT repeat-containing protein 1 | polymer | 2144 | 242649.7 | 1 | UniProt (Q9H583) Pfam (PF12397) Pfam (PF23243) Pfam (PF08146) | Homo sapiens (Human) | Protein BAP28,U3 small nucleolar RNA-associated protein 10 homolog |
| 62 | MB (N0) | 5' ETS rRNA | polymer | 22 | 7197.6 | 1 | Homo sapiens (Human) | ||
| 63 | NB (SG) | U3 small nucleolar RNA-interacting protein 2 | polymer | 475 | 51920.7 | 1 | UniProt (O43818) Pfam (PF00400) | Homo sapiens (Human) | RRP9 homolog,U3 small nucleolar ribonucleoprotein-associated 55 kDa protein,U3 snoRNP-associated 55 kDa protein,U3-55K |
| 64 | OB (NI) | Ribosomal RNA-processing protein 7 homolog A | polymer | 280 | 32393.2 | 1 | UniProt (Q9Y3A4) Pfam (PF17799) Pfam (PF12923) | Homo sapiens (Human) | Gastric cancer antigen Zg14 |
| 65 | PB (SW) | RNA-binding protein PNO1 | polymer | 252 | 27970.4 | 1 | UniProt (Q9NRX1) Pfam (PF22891) | Homo sapiens (Human) | Partner of NOB1 |
| 66 | QB (ST) | Nucleolar protein 14 | polymer | 632 | 68259.5 | 1 | Pfam (PF04147) UniProt (by SIFTS) (P78316) | Homo sapiens (Human) | |
| 67 | RB (SU) | Nucleolar complex protein 4 homolog | polymer | 472 | 50184.1 | 1 | Pfam (PF03914) UniProt (by SIFTS) (Q9BVI4) | Homo sapiens (Human) | |
| 68 | TB (NY) | KRR1 small subunit processome component homolog | polymer | 381 | 43751.1 | 1 | UniProt (Q13601) Pfam (PF21800) Pfam (PF17903) | Homo sapiens (Human) | HIV-1 Rev-binding protein 2,KRR-R motif-containing protein 1,Rev-interacting protein 1,Rip-1 |
| 69 | UB (SZ) | Bystin | polymer | 304 | 33712.9 | 1 | Pfam (PF05291) UniProt (by SIFTS) (Q13895) | Homo sapiens (Human) | |
| 70 | AC, BC, CC, DC, EC... (L1, SI, SL, NH) | MAGNESIUM ION | non-polymer | 24.3 | 22 | Chemie (MG) PubChem (888) | |||
| 71 | PC, QC, UC (NQ, NT, SL) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 72 | RC (SI) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 73 | TC, ZC (SK, SJ) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 74 | WC, YC (NH, NK) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 74 |
| Total formula weight | 5733592.1 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 3037.3 | |
| All* | Total formula weight | 5736629.4 |
