7M2N
Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | L-lactate dehydrogenase A chain | polymer | 338 | 37563.5 | 4 | UniProt (P00338) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (Human) | LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59 |
| 2 | E, JA, NB, RC (A, B, C, D) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 4 | Chemie (NAI) | |||
| 3 | AA, DD, EA, F, HA... (A, D, B, C) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | AB, AC, AD, BA, BC... (B, C, D, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 75 | Chemie (EDO) | |||
| 5 | CC, DC, FB, GC, M... (C, B, A, D) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | CB, FA, IB, N, RA... (B, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 6 | Chemie (PEG) | |||
| 7 | BB, BD, EC, X (B, D, C, A) | 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid | non-polymer | 733.7 | 4 | Chemie (YOJ) | |||
| 8 | FD, GD, HD, ID (A, B, C, D) | water | water | 18.0 | 537 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 331 (UniProt: P00338)
| PDB | External Database | Details |
|---|---|---|
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150254.2 | |
| Non-Polymers* | Number of molecules | 105 |
| Total formula weight | 12401.7 | |
| All* | Total formula weight | 162655.8 |
