7M2N
Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1990204 | cellular_component | oxidoreductase complex |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1990204 | cellular_component | oxidoreductase complex |
| C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045296 | molecular_function | cadherin binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1990204 | cellular_component | oxidoreductase complex |
| D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0045296 | molecular_function | cadherin binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 1990204 | cellular_component | oxidoreductase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue NAI A 401 |
| Chain | Residue |
| A | GLY28 |
| A | ARG98 |
| A | ILE115 |
| A | ILE119 |
| A | VAL135 |
| A | SER136 |
| A | ASN137 |
| A | SER160 |
| A | HIS192 |
| A | THR247 |
| A | ILE251 |
| A | ALA29 |
| A | EDO414 |
| A | YOJ420 |
| A | HOH503 |
| A | HOH506 |
| A | HOH517 |
| A | HOH545 |
| A | HOH562 |
| A | HOH568 |
| A | HOH574 |
| A | HOH589 |
| A | VAL30 |
| A | HOH592 |
| A | ASP51 |
| A | VAL52 |
| A | ILE53 |
| A | THR94 |
| A | ALA95 |
| A | GLY96 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | HIS185 |
| A | HOH507 |
| A | HOH561 |
| A | HOH571 |
| A | HOH582 |
| A | HOH586 |
| C | ARG170 |
| C | HIS185 |
| C | GOL419 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | YOJ420 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | GLN65 |
| A | PRO74 |
| A | ILE76 |
| B | GLU175 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | TRP147 |
| A | LYS148 |
| A | GLY151 |
| A | PHE152 |
| A | HOH525 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | ARG176 |
| A | GLU228 |
| A | HOH536 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | LEU39 |
| A | MET40 |
| A | ASP42 |
| A | PHE70 |
| A | LEU71 |
| A | ARG72 |
| A | HOH554 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | GLU54 |
| A | EDO422 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 409 |
| Chain | Residue |
| A | TYR126 |
| D | LYS148 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 410 |
| Chain | Residue |
| A | LYS148 |
| A | GLN330 |
| A | PHE331 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | ASN163 |
| A | SER166 |
| A | ARG170 |
| A | VAL269 |
| A | PRO271 |
| A | EDO421 |
| A | SO4427 |
| B | LEU69 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | SER201 |
| A | GLY207 |
| C | SER201 |
| C | GLY207 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | THR2 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | ALA97 |
| A | ASN112 |
| A | ASN137 |
| A | NAI401 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | TRP147 |
| A | LYS154 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | LYS148 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue PEG A 417 |
| Chain | Residue |
| A | PRO198 |
| A | TRP200 |
| A | LYS227 |
| A | HIS230 |
| A | GLU310 |
| A | GLU311 |
| A | ARG314 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | ASN87 |
| A | SER127 |
| A | PRO128 |
| A | ASN129 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 419 |
| Chain | Residue |
| A | MET263 |
| D | GLN19 |
| A | ASN20 |
| A | LYS89 |
| site_id | AE2 |
| Number of Residues | 22 |
| Details | binding site for residue YOJ A 420 |
| Chain | Residue |
| A | ARG105 |
| A | LEU106 |
| A | LEU108 |
| A | VAL109 |
| A | ASN137 |
| A | PRO138 |
| A | VAL139 |
| A | ASP140 |
| A | ILE141 |
| A | LEU164 |
| A | ARG168 |
| A | GLU191 |
| A | HIS192 |
| A | ALA237 |
| A | TYR238 |
| A | THR247 |
| A | LEU322 |
| A | ILE325 |
| A | NAI401 |
| A | EDO403 |
| A | HOH597 |
| A | HOH622 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 421 |
| Chain | Residue |
| A | ASP257 |
| A | ARG268 |
| A | HIS270 |
| A | EDO411 |
| A | SO4427 |
| A | HOH583 |
| A | HOH596 |
| B | HOH606 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 422 |
| Chain | Residue |
| A | GLU54 |
| A | GLY79 |
| A | LYS80 |
| A | ASP81 |
| A | EDO408 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 423 |
| Chain | Residue |
| A | LEU213 |
| A | HIS214 |
| A | PRO215 |
| B | GLN6 |
| site_id | AE6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 424 |
| Chain | Residue |
| A | HOH547 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 425 |
| Chain | Residue |
| A | TYR171 |
| A | GLY174 |
| A | GLU175 |
| A | VAL179 |
| A | PRO181 |
| B | HOH571 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 426 |
| Chain | Residue |
| A | TYR246 |
| A | HOH533 |
| A | HOH542 |
| A | HOH624 |
| B | TYR246 |
| B | EDO417 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 427 |
| Chain | Residue |
| A | ARG170 |
| A | HIS185 |
| A | EDO411 |
| A | EDO421 |
| A | HOH534 |
| A | HOH591 |
| C | HIS185 |
| C | HOH518 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 428 |
| Chain | Residue |
| A | MET40 |
| A | ASP42 |
| D | MET40 |
| D | ASP42 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 401 |
| Chain | Residue |
| B | GLU328 |
| B | YOJ422 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| A | THR219 |
| A | ASP220 |
| A | LYS221 |
| B | SER104 |
| B | ARG105 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| A | THR308 |
| A | SER309 |
| B | ASN107 |
| site_id | AF5 |
| Number of Residues | 27 |
| Details | binding site for residue NAI B 404 |
| Chain | Residue |
| B | VAL25 |
| B | GLY28 |
| B | ALA29 |
| B | VAL30 |
| B | ASP51 |
| B | VAL52 |
| B | ILE53 |
| B | LYS56 |
| B | THR94 |
| B | ALA95 |
| B | GLY96 |
| B | ARG98 |
| B | ILE115 |
| B | VAL135 |
| B | SER136 |
| B | ASN137 |
| B | SER160 |
| B | HIS192 |
| B | THR247 |
| B | ILE251 |
| B | YOJ422 |
| B | EDO424 |
| B | HOH513 |
| B | HOH545 |
| B | HOH576 |
| B | HOH581 |
| B | HOH583 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | LEU39 |
| B | MET40 |
| B | ASP42 |
| B | PHE70 |
| B | LEU71 |
| B | ARG72 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | VAL52 |
| B | ILE53 |
| B | GLU54 |
| B | ASP55 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | GLN19 |
| B | ASN20 |
| B | LYS89 |
| B | MET263 |
| C | GLN19 |
| site_id | AF9 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 408 |
| Chain | Residue |
| B | ARG170 |
| B | HIS185 |
| B | GOL426 |
| B | EDO428 |
| B | HOH562 |
| B | HOH586 |
| D | HIS185 |
| D | HOH514 |
| D | HOH578 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| B | MET61 |
| B | VAL77 |
| B | SER78 |
| B | HOH532 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 410 |
| Chain | Residue |
| B | TYR144 |
| B | GLN326 |
| B | LEU329 |
| B | PHE331 |
| B | HIS333 |
| B | HOH515 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 411 |
| Chain | Residue |
| B | LYS242 |
| site_id | AG4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 412 |
| Chain | Residue |
| B | ARG105 |
| B | YOJ422 |
| site_id | AG5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 413 |
| Chain | Residue |
| B | ARG267 |
| B | HOH552 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 414 |
| Chain | Residue |
| B | LEU279 |
| B | LYS304 |
| site_id | AG7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 415 |
| Chain | Residue |
| B | ASP220 |
| B | LYS221 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 416 |
| Chain | Residue |
| B | ASN155 |
| B | ARG156 |
| B | HOH595 |
| C | GLU14 |
| site_id | AG9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 417 |
| Chain | Residue |
| A | TRP249 |
| A | EDO426 |
| B | ALA29 |
| B | ALA33 |
| B | SER248 |
| B | TRP249 |
| B | HOH600 |
| site_id | AH1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 418 |
| Chain | Residue |
| B | HIS332 |
| B | HIS333 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 419 |
| Chain | Residue |
| A | LYS316 |
| B | LYS117 |
| B | GLN330 |
| B | HIS332 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 420 |
| Chain | Residue |
| B | GLU54 |
| B | ASP55 |
| B | LYS58 |
| B | HOH517 |
| site_id | AH4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 421 |
| Chain | Residue |
| B | TRP323 |
| B | LYS327 |
| site_id | AH5 |
| Number of Residues | 23 |
| Details | binding site for residue YOJ B 422 |
| Chain | Residue |
| B | ARG105 |
| B | LEU106 |
| B | LEU108 |
| B | VAL109 |
| B | ASN137 |
| B | PRO138 |
| B | VAL139 |
| B | ASP140 |
| B | ILE141 |
| B | ARG168 |
| B | GLU191 |
| B | HIS192 |
| B | GLY193 |
| B | ALA237 |
| B | TYR238 |
| B | THR247 |
| B | LEU322 |
| B | ILE325 |
| B | EDO401 |
| B | NAI404 |
| B | PEG412 |
| B | HOH578 |
| B | HOH629 |
| site_id | AH6 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 423 |
| Chain | Residue |
| B | SER309 |
| site_id | AH7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 424 |
| Chain | Residue |
| B | NAI404 |
| B | EDO425 |
| site_id | AH8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 425 |
| Chain | Residue |
| B | ALA97 |
| B | ARG98 |
| B | GLN100 |
| B | ARG111 |
| B | EDO424 |
| site_id | AH9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 426 |
| Chain | Residue |
| A | LEU69 |
| B | ASN163 |
| B | SER166 |
| B | ARG170 |
| B | TRP187 |
| B | VAL269 |
| B | PRO271 |
| B | SO4408 |
| B | EDO428 |
| site_id | AI1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 427 |
| Chain | Residue |
| B | LEU172 |
| B | ARG176 |
| site_id | AI2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 428 |
| Chain | Residue |
| B | LEU182 |
| B | ASP257 |
| B | ARG268 |
| B | SO4408 |
| B | GOL426 |
| B | HOH541 |
| B | HOH575 |
| site_id | AI3 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 429 |
| Chain | Residue |
| B | GLN19 |
| B | HOH508 |
| C | LYS89 |
| C | LYS131 |
| C | GLN296 |
| C | HOH502 |
| site_id | AI4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 430 |
| Chain | Residue |
| B | PRO18 |
| B | GLN19 |
| B | LYS89 |
| C | GLN19 |
| site_id | AI5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 401 |
| Chain | Residue |
| C | LYS304 |
| C | HOH557 |
| site_id | AI6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| B | TRP147 |
| B | PRO153 |
| B | LYS154 |
| C | LYS327 |
| C | HOH507 |
| site_id | AI7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 403 |
| Chain | Residue |
| C | PRO153 |
| C | ASN155 |
| C | ARG156 |
| site_id | AI8 |
| Number of Residues | 26 |
| Details | binding site for residue NAI C 404 |
| Chain | Residue |
| C | GLY28 |
| C | ALA29 |
| C | VAL30 |
| C | ASP51 |
| C | VAL52 |
| C | ILE53 |
| C | LYS56 |
| C | THR94 |
| C | ALA95 |
| C | GLY96 |
| C | ARG98 |
| C | ILE115 |
| C | VAL135 |
| C | SER136 |
| C | ASN137 |
| C | SER160 |
| C | HIS192 |
| C | THR247 |
| C | ILE251 |
| C | EDO409 |
| C | YOJ421 |
| C | HOH508 |
| C | HOH521 |
| C | HOH527 |
| C | HOH548 |
| C | HOH568 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | GLN65 |
| C | PRO74 |
| C | LYS75 |
| C | ILE76 |
| D | TYR171 |
| D | GLU175 |
| site_id | AJ1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| C | ARG176 |
| C | VAL229 |
| C | HOH523 |
| site_id | AJ2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 407 |
| Chain | Residue |
| C | LEU39 |
| C | ASP42 |
| C | ARG72 |
| C | HOH535 |
| site_id | AJ3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 408 |
| Chain | Residue |
| C | ASN163 |
| C | SER166 |
| C | ARG170 |
| C | GOL419 |
| site_id | AJ4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 409 |
| Chain | Residue |
| C | ALA97 |
| C | ARG98 |
| C | NAI404 |
| site_id | AJ5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 410 |
| Chain | Residue |
| C | TRP147 |
| C | LYS154 |
| C | HOH520 |
| site_id | AJ6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 411 |
| Chain | Residue |
| C | ASP222 |
| C | LYS223 |
| C | HOH547 |
| site_id | AJ7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 412 |
| Chain | Residue |
| C | GLU191 |
| C | SER195 |
| C | THR321 |
| site_id | AJ8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 413 |
| Chain | Residue |
| C | PRO198 |
| C | TRP200 |
| C | HIS230 |
| C | ARG314 |
| site_id | AJ9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 414 |
| Chain | Residue |
| C | ASP220 |
| C | LYS221 |
| C | LYS227 |
| site_id | AK1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 415 |
| Chain | Residue |
| C | SER309 |
| C | HOH532 |
| site_id | AK2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 416 |
| Chain | Residue |
| C | GLU239 |
| D | LYS58 |
| site_id | AK3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 417 |
| Chain | Residue |
| C | GOL420 |
| C | EDO422 |
| site_id | AK4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 418 |
| Chain | Residue |
| C | TYR9 |
| C | TRP323 |
| C | LYS327 |
| site_id | AK5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 419 |
| Chain | Residue |
| A | SO4402 |
| C | ASP257 |
| C | ARG268 |
| C | HIS270 |
| C | EDO408 |
| C | HOH544 |
| site_id | AK6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 420 |
| Chain | Residue |
| C | GLU235 |
| C | LYS242 |
| C | EDO417 |
| C | EDO422 |
| site_id | AK7 |
| Number of Residues | 15 |
| Details | binding site for residue YOJ C 421 |
| Chain | Residue |
| C | LEU108 |
| C | VAL109 |
| C | ASN137 |
| C | PRO138 |
| C | VAL139 |
| C | ASP140 |
| C | ILE141 |
| C | ARG168 |
| C | GLU191 |
| C | HIS192 |
| C | ALA237 |
| C | TYR238 |
| C | THR247 |
| C | LEU322 |
| C | NAI404 |
| site_id | AK8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 422 |
| Chain | Residue |
| C | LYS242 |
| C | EDO417 |
| C | GOL420 |
| site_id | AK9 |
| Number of Residues | 1 |
| Details | binding site for residue GOL C 423 |
| Chain | Residue |
| C | TYR238 |
| site_id | AL1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| B | HIS185 |
| D | ARG170 |
| D | HIS185 |
| D | EDO414 |
| D | HOH507 |
| D | HOH526 |
| D | HOH542 |
| site_id | AL2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 402 |
| Chain | Residue |
| A | LEU266 |
| A | ARG267 |
| C | VAL179 |
| C | HIS180 |
| D | PRO74 |
| site_id | AL3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 403 |
| Chain | Residue |
| B | GLY207 |
| D | SER201 |
| D | GLY207 |
| site_id | AL4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 404 |
| Chain | Residue |
| D | ARG176 |
| D | GLU228 |
| D | VAL229 |
| D | HOH565 |
| site_id | AL5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 405 |
| Chain | Residue |
| D | GLU54 |
| D | LEU57 |
| D | LYS58 |
| D | SER78 |
| site_id | AL6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 406 |
| Chain | Residue |
| D | GLY79 |
| D | LYS80 |
| D | ASP81 |
| site_id | AL7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 407 |
| Chain | Residue |
| D | ALA97 |
| D | ARG98 |
| D | ARG111 |
| D | HOH550 |
| site_id | AL8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 408 |
| Chain | Residue |
| D | LYS56 |
| D | ARG98 |
| site_id | AL9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 409 |
| Chain | Residue |
| D | GLN100 |
| D | ASN107 |
| D | ARG111 |
| D | HOH534 |
| D | HOH534 |
| site_id | AM1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 410 |
| Chain | Residue |
| D | MET40 |
| D | ASP42 |
| D | PHE70 |
| D | ARG72 |
| D | HOH544 |
| site_id | AM2 |
| Number of Residues | 30 |
| Details | binding site for residue NAI D 411 |
| Chain | Residue |
| D | VAL25 |
| D | GLY28 |
| D | ALA29 |
| D | VAL30 |
| D | ASP51 |
| D | VAL52 |
| D | ILE53 |
| D | LYS56 |
| D | THR94 |
| D | ALA95 |
| D | GLY96 |
| D | ARG98 |
| D | ILE115 |
| D | ILE119 |
| D | VAL135 |
| D | SER136 |
| D | ASN137 |
| D | SER160 |
| D | HIS192 |
| D | THR247 |
| D | ILE251 |
| D | YOJ421 |
| D | HOH502 |
| D | HOH505 |
| D | HOH519 |
| D | HOH521 |
| D | HOH550 |
| D | HOH551 |
| D | HOH560 |
| D | HOH572 |
| site_id | AM3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 412 |
| Chain | Residue |
| A | PRO74 |
| D | ASN265 |
| D | LEU266 |
| D | ARG267 |
| D | HOH604 |
| site_id | AM4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 413 |
| Chain | Residue |
| D | ASN265 |
| D | ARG267 |
| D | GLY295 |
| D | GLN296 |
| D | ASN297 |
| D | GLY298 |
| D | HOH571 |
| site_id | AM5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 414 |
| Chain | Residue |
| C | LEU69 |
| D | SER166 |
| D | ARG170 |
| D | VAL269 |
| D | SO4401 |
| D | EDO424 |
| D | HOH553 |
| site_id | AM6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 415 |
| Chain | Residue |
| D | TYR9 |
| D | ASN10 |
| D | HOH518 |
| site_id | AM7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 416 |
| Chain | Residue |
| D | TRP147 |
| D | PRO153 |
| D | LYS154 |
| site_id | AM8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 417 |
| Chain | Residue |
| D | SER309 |
| site_id | AM9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 418 |
| Chain | Residue |
| D | LYS242 |
| site_id | AN1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 419 |
| Chain | Residue |
| D | LYS125 |
| site_id | AN2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 420 |
| Chain | Residue |
| A | ASP81 |
| D | TRP323 |
| D | LYS327 |
| site_id | AN3 |
| Number of Residues | 20 |
| Details | binding site for residue YOJ D 421 |
| Chain | Residue |
| D | ARG105 |
| D | LEU106 |
| D | LEU108 |
| D | VAL109 |
| D | ASN137 |
| D | PRO138 |
| D | VAL139 |
| D | ASP140 |
| D | ILE141 |
| D | LEU164 |
| D | ARG168 |
| D | GLU191 |
| D | HIS192 |
| D | TYR238 |
| D | THR247 |
| D | LEU322 |
| D | ILE325 |
| D | NAI411 |
| D | EDO422 |
| D | SO4423 |
| site_id | AN4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 422 |
| Chain | Residue |
| D | TYR238 |
| D | YOJ421 |
| site_id | AN5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 423 |
| Chain | Residue |
| D | SER104 |
| D | SER104 |
| D | ARG105 |
| D | ARG105 |
| D | YOJ421 |
| site_id | AN6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 424 |
| Chain | Residue |
| D | ASP257 |
| D | ARG268 |
| D | HIS270 |
| D | EDO414 |
| D | HOH553 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU189-SER195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS192 | |
| B | HIS192 | |
| C | HIS192 | |
| D | HIS192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11276087 |
| Chain | Residue | Details |
| A | GLY28 | |
| A | ARG98 | |
| B | GLY28 | |
| B | ARG98 | |
| C | GLY28 | |
| C | ARG98 | |
| D | GLY28 | |
| D | ARG98 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG105 | |
| C | ASN137 | |
| C | ARG168 | |
| C | THR247 | |
| D | ARG105 | |
| D | ASN137 | |
| D | ARG168 | |
| D | THR247 | |
| A | ASN137 | |
| A | ARG168 | |
| A | THR247 | |
| B | ARG105 | |
| B | ASN137 | |
| B | ARG168 | |
| B | THR247 | |
| C | ARG105 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | ALA1 | |
| B | ALA1 | |
| C | ALA1 | |
| D | ALA1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| A | LYS4 | |
| D | LYS4 | |
| D | LYS117 | |
| D | LYS317 | |
| A | LYS117 | |
| A | LYS317 | |
| B | LYS4 | |
| B | LYS117 | |
| B | LYS317 | |
| C | LYS4 | |
| C | LYS117 | |
| C | LYS317 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR9 | |
| B | TYR9 | |
| C | TYR9 | |
| D | TYR9 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS13 | |
| D | LYS13 | |
| D | LYS80 | |
| D | LYS125 | |
| A | LYS80 | |
| A | LYS125 | |
| B | LYS13 | |
| B | LYS80 | |
| B | LYS125 | |
| C | LYS13 | |
| C | LYS80 | |
| C | LYS125 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR17 | |
| B | THR17 | |
| C | THR17 | |
| D | THR17 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS56 | |
| B | LYS56 | |
| C | LYS56 | |
| D | LYS56 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| A | LYS223 | |
| D | LYS223 | |
| D | LYS231 | |
| D | LYS242 | |
| A | LYS231 | |
| A | LYS242 | |
| B | LYS223 | |
| B | LYS231 | |
| B | LYS242 | |
| C | LYS223 | |
| C | LYS231 | |
| C | LYS242 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151 |
| Chain | Residue | Details |
| A | TYR238 | |
| B | TYR238 | |
| C | TYR238 | |
| D | TYR238 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642 |
| Chain | Residue | Details |
| A | THR308 | |
| A | THR321 | |
| B | THR308 | |
| B | THR321 | |
| C | THR308 | |
| C | THR321 | |
| D | THR308 | |
| D | THR321 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER309 | |
| B | SER309 | |
| C | SER309 | |
| D | SER309 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS56 | |
| B | LYS56 | |
| C | LYS56 | |
| D | LYS56 |
