7M0L
HPK1 IN COMPLEX WITH COMPOUND 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 290 | 32587.9 | 4 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (Human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | E, F, G, H (A, B, C, D) | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | non-polymer | 483.4 | 4 | Chemie (YK4) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 294 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Glu 165 | Thr 165 | conflict |
| Glu 171 | Ser 171 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130351.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1933.4 | |
| All* | Total formula weight | 132284.9 |
