7M0L

HPK1 IN COMPLEX WITH COMPOUND 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue YK4 A 301

Chain	Residue
A	LEU23
A	GLY95
A	GLY97
A	ASP101
A	LEU144
A	TYR28
A	VAL31
A	ALA44
A	VAL75
A	MET91
A	GLU92
A	PHE93
A	CYS94

---

site_id	AC2
Number of Residues	13
Details	binding site for residue YK4 B 301

Chain	Residue
B	LEU23
B	GLY24
B	TYR28
B	VAL31
B	ALA44
B	VAL75
B	MET91
B	GLU92
B	CYS94
B	GLY95
B	GLY97
B	ASP101
B	LEU144

---

site_id	AC3
Number of Residues	13
Details	binding site for residue YK4 C 301

Chain	Residue
C	LEU23
C	TYR28
C	VAL31
C	ALA44
C	VAL75
C	MET91
C	GLU92
C	CYS94
C	GLY95
C	GLY97
C	ASP101
C	LEU144
C	PHE156

---

site_id	AC4
Number of Residues	13
Details	binding site for residue YK4 D 301

Chain	Residue
D	LEU23
D	TYR28
D	VAL31
D	ALA44
D	VAL75
D	MET91
D	GLU92
D	PHE93
D	CYS94
D	GLY95
D	GLY97
D	ASP101
D	LEU144

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGTYGEVFkArdkvsgdl..........VALK

Chain	Residue	Details
A	LEU23-LYS46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP137
B	ASP137
C	ASP137
D	ASP137

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
C	LEU23
C	LYS46
D	LEU23
D	LYS46
A	LYS46
B	LEU23
B	LYS46
A	LEU23

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:24362026

Chain	Residue	Details
C	GLU165
C	THR175
D	GLU165
D	THR175
A	THR175
B	GLU165
B	THR175
A	GLU165

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:24362026

Chain	Residue	Details
C	GLU171
D	GLU171
A	GLU171
B	GLU171

---