7LUR
Stable Effector Functionless 2 (SEFL2) IgG1 Fc Scaffold Bound to a Minimized Version of the B-domain (Mini-Z) from Protein A Called Z34C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin heavy constant gamma 1 | polymer | 227 | 25505.9 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE |
| 2 | C, D (C, D) | Mini Z domain | polymer | 34 | 4190.7 | 2 | Staphylococcus aureus | ||
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B: 221 - 447 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Cys 292 | Arg 175 | engineered mutation |
| Gly 297 | Asn 180 | engineered mutation |
| Cys 302 | Val 185 | engineered mutation |
| Glu 356 | Asp 239 | variant |
| Met 358 | Leu 241 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59393.2 | |
| All* | Total formula weight | 59393.2 |
