7KW7
Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-alpha | polymer | 732 | 84781.7 | 2 | UniProt (P07900) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C, D (C, D) | Heat shock 70 kDa protein 1A | polymer | 641 | 70140.1 | 2 | UniProt (P0DMV8) Pfam (PF00012) | Homo sapiens (Human) | Heat shock 70 kDa protein 1,HSP70.1 |
| 3 | E (E) | Stress-induced-phosphoprotein 1 | polymer | 543 | 62738.3 | 1 | UniProt (P31948) Pfam (PF17830) Pfam (PF13181) Pfam (PF00515) | Homo sapiens (Human) | STI1,Hsc70/Hsp90-organizing protein,Hop,Renal carcinoma antigen NY-REN-11,Transformation-sensitive protein IEF SSP 3521 |
| 4 | F (F) | Glucocorticoid receptor | polymer | 777 | 85673.9 | 1 | UniProt (P04150) Pfam (PF02155) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 5 | G, J (C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 6 | H, K (C, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | I, L (C, D) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) |
Sequence modifications
F: 1 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 519 | Thr 519 | conflict |
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 458255.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 981.2 | |
| All* | Total formula weight | 459237.1 |
