7KW7

Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001764	biological_process	neuron migration
A	0002134	molecular_function	UTP binding
A	0002135	molecular_function	CTP binding
A	0002218	biological_process	activation of innate immune response
A	0002230	biological_process	positive regulation of defense response to virus by host
A	0003009	biological_process	skeletal muscle contraction
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006457	biological_process	protein folding
A	0006839	biological_process	mitochondrial transport
A	0006986	biological_process	response to unfolded protein
A	0007004	biological_process	telomere maintenance via telomerase
A	0009408	biological_process	response to heat
A	0009409	biological_process	response to cold
A	0009410	biological_process	response to xenobiotic stimulus
A	0009651	biological_process	response to salt stress
A	0009986	cellular_component	cell surface
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017098	molecular_function	sulfonylurea receptor binding
A	0019903	molecular_function	protein phosphatase binding
A	0023026	molecular_function	MHC class II protein complex binding
A	0030150	biological_process	protein import into mitochondrial matrix
A	0030235	molecular_function	nitric-oxide synthase regulator activity
A	0030911	molecular_function	TPR domain binding
A	0031012	cellular_component	extracellular matrix
A	0031396	biological_process	regulation of protein ubiquitination
A	0031526	cellular_component	brush border membrane
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0032273	biological_process	positive regulation of protein polymerization
A	0032564	molecular_function	dATP binding
A	0032728	biological_process	positive regulation of interferon-beta production
A	0032880	biological_process	regulation of protein localization
A	0032991	cellular_component	protein-containing complex
A	0034605	biological_process	cellular response to heat
A	0034774	cellular_component	secretory granule lumen
A	0036126	cellular_component	sperm flagellum
A	0042026	biological_process	protein refolding
A	0042220	biological_process	response to cocaine
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042826	molecular_function	histone deacetylase binding
A	0042981	biological_process	regulation of apoptotic process
A	0043025	cellular_component	neuronal cell body
A	0043202	cellular_component	lysosomal lumen
A	0043209	cellular_component	myelin sheath
A	0043254	biological_process	regulation of protein-containing complex assembly
A	0043335	biological_process	protein unfolding
A	0043627	biological_process	response to estrogen
A	0044183	molecular_function	protein folding chaperone
A	0044294	cellular_component	dendritic growth cone
A	0044295	cellular_component	axonal growth cone
A	0044325	molecular_function	transmembrane transporter binding
A	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045793	biological_process	positive regulation of cell size
A	0046209	biological_process	nitric oxide metabolic process
A	0046677	biological_process	response to antibiotic
A	0048156	molecular_function	tau protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050821	biological_process	protein stabilization
A	0051020	molecular_function	GTPase binding
A	0051022	molecular_function	Rho GDP-dissociation inhibitor binding
A	0051082	molecular_function	unfolded protein binding
A	0051131	biological_process	chaperone-mediated protein complex assembly
A	0060452	biological_process	positive regulation of cardiac muscle contraction
A	0061684	biological_process	chaperone-mediated autophagy
A	0070062	cellular_component	extracellular exosome
A	0070182	molecular_function	DNA polymerase binding
A	0071682	cellular_component	endocytic vesicle lumen
A	0097110	molecular_function	scaffold protein binding
A	0097226	cellular_component	sperm mitochondrial sheath
A	0097524	cellular_component	sperm plasma membrane
A	0097718	molecular_function	disordered domain specific binding
A	0098586	biological_process	cellular response to virus
A	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
A	0101031	cellular_component	protein folding chaperone complex
A	0140662	molecular_function	ATP-dependent protein folding chaperone
A	0140767	molecular_function	enzyme-substrate adaptor activity
A	1902988	biological_process	neurofibrillary tangle assembly
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1905323	biological_process	telomerase holoenzyme complex assembly
A	1990782	molecular_function	protein tyrosine kinase binding
B	0000166	molecular_function	nucleotide binding
B	0001764	biological_process	neuron migration
B	0002134	molecular_function	UTP binding
B	0002135	molecular_function	CTP binding
B	0002218	biological_process	activation of innate immune response
B	0002230	biological_process	positive regulation of defense response to virus by host
B	0003009	biological_process	skeletal muscle contraction
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006457	biological_process	protein folding
B	0006839	biological_process	mitochondrial transport
B	0006986	biological_process	response to unfolded protein
B	0007004	biological_process	telomere maintenance via telomerase
B	0009408	biological_process	response to heat
B	0009409	biological_process	response to cold
B	0009410	biological_process	response to xenobiotic stimulus
B	0009651	biological_process	response to salt stress
B	0009986	cellular_component	cell surface
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0010659	biological_process	cardiac muscle cell apoptotic process
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017098	molecular_function	sulfonylurea receptor binding
B	0019903	molecular_function	protein phosphatase binding
B	0023026	molecular_function	MHC class II protein complex binding
B	0030150	biological_process	protein import into mitochondrial matrix
B	0030235	molecular_function	nitric-oxide synthase regulator activity
B	0030911	molecular_function	TPR domain binding
B	0031012	cellular_component	extracellular matrix
B	0031396	biological_process	regulation of protein ubiquitination
B	0031526	cellular_component	brush border membrane
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0032273	biological_process	positive regulation of protein polymerization
B	0032564	molecular_function	dATP binding
B	0032728	biological_process	positive regulation of interferon-beta production
B	0032880	biological_process	regulation of protein localization
B	0032991	cellular_component	protein-containing complex
B	0034605	biological_process	cellular response to heat
B	0034774	cellular_component	secretory granule lumen
B	0036126	cellular_component	sperm flagellum
B	0042026	biological_process	protein refolding
B	0042220	biological_process	response to cocaine
B	0042307	biological_process	positive regulation of protein import into nucleus
B	0042470	cellular_component	melanosome
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042826	molecular_function	histone deacetylase binding
B	0042981	biological_process	regulation of apoptotic process
B	0043025	cellular_component	neuronal cell body
B	0043202	cellular_component	lysosomal lumen
B	0043209	cellular_component	myelin sheath
B	0043254	biological_process	regulation of protein-containing complex assembly
B	0043335	biological_process	protein unfolding
B	0043627	biological_process	response to estrogen
B	0044183	molecular_function	protein folding chaperone
B	0044294	cellular_component	dendritic growth cone
B	0044295	cellular_component	axonal growth cone
B	0044325	molecular_function	transmembrane transporter binding
B	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045793	biological_process	positive regulation of cell size
B	0046209	biological_process	nitric oxide metabolic process
B	0046677	biological_process	response to antibiotic
B	0048156	molecular_function	tau protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050821	biological_process	protein stabilization
B	0051020	molecular_function	GTPase binding
B	0051022	molecular_function	Rho GDP-dissociation inhibitor binding
B	0051082	molecular_function	unfolded protein binding
B	0051131	biological_process	chaperone-mediated protein complex assembly
B	0060452	biological_process	positive regulation of cardiac muscle contraction
B	0061684	biological_process	chaperone-mediated autophagy
B	0070062	cellular_component	extracellular exosome
B	0070182	molecular_function	DNA polymerase binding
B	0071682	cellular_component	endocytic vesicle lumen
B	0097110	molecular_function	scaffold protein binding
B	0097226	cellular_component	sperm mitochondrial sheath
B	0097524	cellular_component	sperm plasma membrane
B	0097718	molecular_function	disordered domain specific binding
B	0098586	biological_process	cellular response to virus
B	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
B	0101031	cellular_component	protein folding chaperone complex
B	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0140767	molecular_function	enzyme-substrate adaptor activity
B	1902988	biological_process	neurofibrillary tangle assembly
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1905323	biological_process	telomerase holoenzyme complex assembly
B	1990782	molecular_function	protein tyrosine kinase binding
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000166	molecular_function	nucleotide binding
C	0001618	molecular_function	virus receptor activity
C	0001664	molecular_function	G protein-coupled receptor binding
C	0003714	molecular_function	transcription corepressor activity
C	0003723	molecular_function	RNA binding
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005813	cellular_component	centrosome
C	0005814	cellular_component	centriole
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006402	biological_process	mRNA catabolic process
C	0006986	biological_process	response to unfolded protein
C	0007041	biological_process	lysosomal transport
C	0008180	cellular_component	COP9 signalosome
C	0008285	biological_process	negative regulation of cell population proliferation
C	0010628	biological_process	positive regulation of gene expression
C	0016234	cellular_component	inclusion body
C	0016235	cellular_component	aggresome
C	0016607	cellular_component	nuclear speck
C	0016887	molecular_function	ATP hydrolysis activity
C	0019899	molecular_function	enzyme binding
C	0030308	biological_process	negative regulation of cell growth
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030968	biological_process	endoplasmic reticulum unfolded protein response
C	0031072	molecular_function	heat shock protein binding
C	0031249	molecular_function	denatured protein binding
C	0031396	biological_process	regulation of protein ubiquitination
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031982	cellular_component	vesicle
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032757	biological_process	positive regulation of interleukin-8 production
C	0032991	cellular_component	protein-containing complex
C	0033120	biological_process	positive regulation of RNA splicing
C	0034599	biological_process	cellular response to oxidative stress
C	0034605	biological_process	cellular response to heat
C	0034620	biological_process	cellular response to unfolded protein
C	0042026	biological_process	protein refolding
C	0042826	molecular_function	histone deacetylase binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044183	molecular_function	protein folding chaperone
C	0045296	molecular_function	cadherin binding
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0046034	biological_process	ATP metabolic process
C	0046718	biological_process	symbiont entry into host cell
C	0048018	molecular_function	receptor ligand activity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050821	biological_process	protein stabilization
C	0051082	molecular_function	unfolded protein binding
C	0051131	biological_process	chaperone-mediated protein complex assembly
C	0051787	molecular_function	misfolded protein binding
C	0055131	molecular_function	C3HC4-type RING finger domain binding
C	0070062	cellular_component	extracellular exosome
C	0070370	biological_process	cellular heat acclimation
C	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
C	0071383	biological_process	cellular response to steroid hormone stimulus
C	0072562	cellular_component	blood microparticle
C	0090063	biological_process	positive regulation of microtubule nucleation
C	0090084	biological_process	negative regulation of inclusion body assembly
C	0097718	molecular_function	disordered domain specific binding
C	0140416	molecular_function	transcription regulator inhibitor activity
C	0140545	molecular_function	ATP-dependent protein disaggregase activity
C	1901029	biological_process	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
C	1901673	biological_process	regulation of mitotic spindle assembly
C	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	1990904	cellular_component	ribonucleoprotein complex
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000166	molecular_function	nucleotide binding
D	0001618	molecular_function	virus receptor activity
D	0001664	molecular_function	G protein-coupled receptor binding
D	0003714	molecular_function	transcription corepressor activity
D	0003723	molecular_function	RNA binding
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006402	biological_process	mRNA catabolic process
D	0006986	biological_process	response to unfolded protein
D	0007041	biological_process	lysosomal transport
D	0008180	cellular_component	COP9 signalosome
D	0008285	biological_process	negative regulation of cell population proliferation
D	0010628	biological_process	positive regulation of gene expression
D	0016234	cellular_component	inclusion body
D	0016235	cellular_component	aggresome
D	0016607	cellular_component	nuclear speck
D	0016887	molecular_function	ATP hydrolysis activity
D	0019899	molecular_function	enzyme binding
D	0030308	biological_process	negative regulation of cell growth
D	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
D	0030968	biological_process	endoplasmic reticulum unfolded protein response
D	0031072	molecular_function	heat shock protein binding
D	0031249	molecular_function	denatured protein binding
D	0031396	biological_process	regulation of protein ubiquitination
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031982	cellular_component	vesicle
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032757	biological_process	positive regulation of interleukin-8 production
D	0032991	cellular_component	protein-containing complex
D	0033120	biological_process	positive regulation of RNA splicing
D	0034599	biological_process	cellular response to oxidative stress
D	0034605	biological_process	cellular response to heat
D	0034620	biological_process	cellular response to unfolded protein
D	0042026	biological_process	protein refolding
D	0042826	molecular_function	histone deacetylase binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044183	molecular_function	protein folding chaperone
D	0045296	molecular_function	cadherin binding
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0046034	biological_process	ATP metabolic process
D	0046718	biological_process	symbiont entry into host cell
D	0048018	molecular_function	receptor ligand activity
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
D	0051131	biological_process	chaperone-mediated protein complex assembly
D	0051787	molecular_function	misfolded protein binding
D	0055131	molecular_function	C3HC4-type RING finger domain binding
D	0070062	cellular_component	extracellular exosome
D	0070370	biological_process	cellular heat acclimation
D	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
D	0071383	biological_process	cellular response to steroid hormone stimulus
D	0072562	cellular_component	blood microparticle
D	0090063	biological_process	positive regulation of microtubule nucleation
D	0090084	biological_process	negative regulation of inclusion body assembly
D	0097718	molecular_function	disordered domain specific binding
D	0140416	molecular_function	transcription regulator inhibitor activity
D	0140545	molecular_function	ATP-dependent protein disaggregase activity
D	1901029	biological_process	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
D	1901673	biological_process	regulation of mitotic spindle assembly
D	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D	1903265	biological_process	positive regulation of tumor necrosis factor-mediated signaling pathway
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	1990904	cellular_component	ribonucleoprotein complex
D	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0032991	cellular_component	protein-containing complex
E	0051879	molecular_function	Hsp90 protein binding
E	0101031	cellular_component	protein folding chaperone complex
E	0120293	cellular_component	dynein axonemal particle
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000785	cellular_component	chromatin
F	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
F	0001046	molecular_function	core promoter sequence-specific DNA binding
F	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
F	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0003707	molecular_function	nuclear steroid receptor activity
F	0003723	molecular_function	RNA binding
F	0004879	molecular_function	nuclear receptor activity
F	0004883	molecular_function	nuclear glucocorticoid receptor activity
F	0005496	molecular_function	steroid binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0006325	biological_process	chromatin organization
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006915	biological_process	apoptotic process
F	0007059	biological_process	chromosome segregation
F	0007165	biological_process	signal transduction
F	0008270	molecular_function	zinc ion binding
F	0008289	molecular_function	lipid binding
F	0014004	biological_process	microglia differentiation
F	0016020	cellular_component	membrane
F	0016607	cellular_component	nuclear speck
F	0017025	molecular_function	TBP-class protein binding
F	0019901	molecular_function	protein kinase binding
F	0030518	biological_process	nuclear receptor-mediated steroid hormone signaling pathway
F	0031958	biological_process	nuclear receptor-mediated corticosteroid signaling pathway
F	0032991	cellular_component	protein-containing complex
F	0034056	molecular_function	estrogen response element binding
F	0035249	biological_process	synaptic transmission, glutamatergic
F	0042802	molecular_function	identical protein binding
F	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
F	0043565	molecular_function	sequence-specific DNA binding
F	0045202	cellular_component	synapse
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046872	molecular_function	metal ion binding
F	0048708	biological_process	astrocyte differentiation
F	0051301	biological_process	cell division
F	0051384	biological_process	response to glucocorticoid
F	0051879	molecular_function	Hsp90 protein binding
F	0061744	biological_process	motor behavior
F	0071383	biological_process	cellular response to steroid hormone stimulus
F	0071385	biological_process	cellular response to glucocorticoid stimulus
F	0071549	biological_process	cellular response to dexamethasone stimulus
F	0071560	biological_process	cellular response to transforming growth factor beta stimulus
F	0150076	biological_process	neuroinflammatory response
F	1901654	biological_process	response to ketone
F	1902895	biological_process	positive regulation of miRNA transcription
F	1990239	molecular_function	steroid hormone binding
F	1990837	molecular_function	sequence-specific double-stranded DNA binding
F	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCs.Deasgc.HYgvltCgsCkvFFkR

Chain	Residue	Details
F	CYS421-ARG447

---

site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS

Chain	Residue	Details
C	ILE9-SER16

---

site_id	PS00298
Number of Residues	10
Details	HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE

Chain	Residue	Details
A	TYR38-GLU47

---

site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL

Chain	Residue	Details
C	ILE197-LEU210

---

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. LvLvGGsTRIPkVqK

Chain	Residue	Details
C	LEU334-LYS348

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P07901","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P07901","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	19
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P82995","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"15937123","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Region: {"description":"Essential for interaction with SMYD3, TSC1 and STIP1/HOP","evidences":[{"source":"PubMed","id":"25738358","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29127155","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Region: {"description":"Essential for interaction with SGTA and TTC1","evidences":[{"source":"PubMed","id":"15708368","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"27708256","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	33
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	33
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	33
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	33
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	33
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	39
Details	Domain: {"description":"STI1 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	17
Details	Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	234
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	165
Details	Region: {"description":"Interaction with CRY1","evidences":[{"source":"PubMed","id":"22170608","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"12144530","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---