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7KRA

Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
ER membrane protein complex subunit 1polymer76087272.91UniProt (P25574)
Pfam (PF07774)
Saccharomyces cerevisiae (Baker's yeast)
2B
(B)
ER membrane protein complex subunit 2polymer29233893.21UniProt (P47133)Saccharomyces cerevisiae (Baker's yeast)
3C
(C)
ER membrane protein complex subunit 3polymer25328372.81UniProt (P36039)
Pfam (PF01956)
Saccharomyces cerevisiae (Baker's yeast)Altered inheritance rate of mitochondria protein 27
4D
(D)
ER membrane protein complex subunit 4polymer19021478.71UniProt (P53073)
Pfam (PF06417)
Saccharomyces cerevisiae (Baker's yeast)
5E
(E)
ER membrane protein complex subunit 5polymer18220489.91UniProt (P40540)
Pfam (PF10270)
Saccharomyces cerevisiae (Baker's yeast)
6F
(F)
ER membrane protein complex subunit 6polymer10812411.41UniProt (Q12431)
Pfam (PF07019)
Saccharomyces cerevisiae (Baker's yeast)
7G
(G)
Protein SOP4polymer23426627.61UniProt (P39543)
Pfam (PF17081)
Saccharomyces cerevisiae (Baker's yeast)Suppressor of PMA1-7 protein 4
8H
(H)
Endoplasmic reticulum membrane protein complex subunit 10polymer20522792.81UniProt (Q12025)
Pfam (PF21203)
Saccharomyces cerevisiae (Baker's yeast)
9I
(I)
Fab DH4 heavy chainpolymer25426850.01Homo sapiens (Human)
10J
(J)
Fab DH4 light chainpolymer23425566.61Homo sapiens (Human)
11K, L
(M, N)
Unassigned helixpolymer242060.52Saccharomyces cerevisiae (Baker's yeast)
12M, N, O, Q, R
(A, G)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.25Chemie (NAG)
13P
(C)
[(2~{R})-1-octanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] nonanoatenon-polymer524.61Chemie (X3P)
Sequence modifications
E: 1 - 141 (UniProt: P40540)
E: 142 - 182 (PDB: 7KRA)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight309877.1
Non-Polymers*Number of molecules6
Total formula weight1630.7
All*Total formula weight311507.8
*Water molecules are not included.

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PDB entries from 2026-01-14

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