7KR5
Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Calcium release-activated calcium channel protein 1 | polymer | 214 | 24160.2 | 6 | UniProt (Q9U6B8) Pfam (PF07856) In PDB | Drosophila melanogaster (Fruit fly) | Protein orai |
2 | H, M, O | 19B5 Fab heavy chain | polymer | 244 | 26886.5 | 3 | Mus musculus | ||
3 | L, N, P | 19B5 Fab light chain | polymer | 232 | 25587.3 | 3 | Mus musculus | ||
4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
A, B, C, D, E, F: 133 - 341 (UniProt: Q9U6B8)
PDB | External Database | Details |
---|---|---|
Ala 206 | His 206 | engineered mutation |
Ser 224 | Cys 224 | engineered mutation |
Thr 283 | Cys 283 | engineered mutation |
Glu 342 | - | expression tag |
Gly 343 | - | expression tag |
Glu 344 | - | expression tag |
Glu 345 | - | expression tag |
Phe 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 302382.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 40.1 | |
All* | Total formula weight | 302422.4 |