7KR5
Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR212-HIS218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 462 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | THR164-LEU181 | |
| C | LEU192-ILE212 | |
| C | ALA249-VAL269 | |
| C | ALA278-ILE298 | |
| D | THR164-LEU181 | |
| D | LEU192-ILE212 | |
| D | ALA249-VAL269 | |
| D | ALA278-ILE298 | |
| E | THR164-LEU181 | |
| E | LEU192-ILE212 | |
| E | ALA249-VAL269 | |
| A | LEU192-ILE212 | |
| E | ALA278-ILE298 | |
| F | THR164-LEU181 | |
| F | LEU192-ILE212 | |
| F | ALA249-VAL269 | |
| F | ALA278-ILE298 | |
| A | ALA249-VAL269 | |
| A | ALA278-ILE298 | |
| B | THR164-LEU181 | |
| B | LEU192-ILE212 | |
| B | ALA249-VAL269 | |
| B | ALA278-ILE298 | |
| C | THR164-LEU181 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 96 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP182-MET191 | |
| E | LYS270-PRO277 | |
| F | ASP182-MET191 | |
| F | LYS270-PRO277 | |
| A | LYS270-PRO277 | |
| B | ASP182-MET191 | |
| B | LYS270-PRO277 | |
| C | ASP182-MET191 | |
| C | LYS270-PRO277 | |
| D | ASP182-MET191 | |
| D | LYS270-PRO277 | |
| E | ASP182-MET191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 210 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | SER213-TRP248 | |
| B | SER213-TRP248 | |
| C | SER213-TRP248 | |
| D | SER213-TRP248 | |
| E | SER213-TRP248 | |
| F | SER213-TRP248 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Confers selective permeability to Ca(2+) ions => ECO:0000250|UniProtKB:Q96D31, ECO:0000305|PubMed:16921383 |
| Chain | Residue | Details |
| A | GLU178 | |
| B | GLU178 | |
| C | GLU178 | |
| D | GLU178 | |
| E | GLU178 | |
| F | GLU178 |
