7KR5
Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
Chain | Residue | Details |
L | TYR212-HIS218 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 462 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | THR164-LEU181 | |
C | LEU192-ILE212 | |
C | ALA249-VAL269 | |
C | ALA278-ILE298 | |
D | THR164-LEU181 | |
D | LEU192-ILE212 | |
D | ALA249-VAL269 | |
D | ALA278-ILE298 | |
E | THR164-LEU181 | |
E | LEU192-ILE212 | |
E | ALA249-VAL269 | |
A | LEU192-ILE212 | |
E | ALA278-ILE298 | |
F | THR164-LEU181 | |
F | LEU192-ILE212 | |
F | ALA249-VAL269 | |
F | ALA278-ILE298 | |
A | ALA249-VAL269 | |
A | ALA278-ILE298 | |
B | THR164-LEU181 | |
B | LEU192-ILE212 | |
B | ALA249-VAL269 | |
B | ALA278-ILE298 | |
C | THR164-LEU181 |
site_id | SWS_FT_FI2 |
Number of Residues | 96 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | ASP182-MET191 | |
E | LYS270-PRO277 | |
F | ASP182-MET191 | |
F | LYS270-PRO277 | |
A | LYS270-PRO277 | |
B | ASP182-MET191 | |
B | LYS270-PRO277 | |
C | ASP182-MET191 | |
C | LYS270-PRO277 | |
D | ASP182-MET191 | |
D | LYS270-PRO277 | |
E | ASP182-MET191 |
site_id | SWS_FT_FI3 |
Number of Residues | 210 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | SER213-TRP248 | |
B | SER213-TRP248 | |
C | SER213-TRP248 | |
D | SER213-TRP248 | |
E | SER213-TRP248 | |
F | SER213-TRP248 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | SITE: Confers selective permeability to Ca(2+) ions => ECO:0000250|UniProtKB:Q96D31, ECO:0000305|PubMed:16921383 |
Chain | Residue | Details |
A | GLU178 | |
B | GLU178 | |
C | GLU178 | |
D | GLU178 | |
E | GLU178 | |
F | GLU178 |