7KHR
Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | V-type proton ATPase catalytic subunit A | polymer | 617 | 68420.9 | 3 | UniProt (P31404) Pfam (PF02874) Pfam (PF16886) Pfam (PF00006) Pfam (PF22919) | Bos taurus (Bovine) | V-ATPase subunit A,V-ATPase 69 kDa subunit,Vacuolar proton pump subunit alpha |
| 2 | D, E, F (D, E, F) | V-type proton ATPase subunit B, brain isoform | polymer | 511 | 56637.6 | 3 | UniProt (P31408) Pfam (PF02874) Pfam (PF00006) Pfam (PF22919) | Bos taurus (Bovine) | V-ATPase subunit B 2,Endomembrane proton pump 58 kDa subunit,Vacuolar proton pump subunit B 2 |
| 3 | G (G) | V-type proton ATPase subunit C 1 | polymer | 382 | 44042.6 | 1 | UniProt (P21282) Pfam (PF03223) | Bos taurus (Bovine) | V-ATPase subunit C 1,Vacuolar proton pump subunit C 1 |
| 4 | H (H) | V-type proton ATPase subunit D | polymer | 247 | 28297.9 | 1 | UniProt (A0A3Q1M4W9) Pfam (PF01813) UniProt (by SIFTS) (P39942) | Bos taurus (Bovine) | |
| 5 | I, J, K (I, J, K) | V-type proton ATPase subunit E 1 | polymer | 226 | 26178.4 | 3 | UniProt (P11019) Pfam (PF01991) | Bos taurus (Bovine) | V-ATPase subunit E 1,V-ATPase 31 kDa subunit,P31,Vacuolar proton pump subunit E 1 |
| 6 | L (L) | V-type proton ATPase subunit F | polymer | 119 | 13417.3 | 1 | UniProt (Q28029) Pfam (PF01990) | Bos taurus (Bovine) | V-ATPase subunit F,V-ATPase 14 kDa subunit,Vacuolar proton pump subunit F |
| 7 | M, N, O (M, N, O) | V-type proton ATPase subunit G | polymer | 118 | 13588.3 | 3 | UniProt (Q0VCV6) Pfam (PF03179) | Bos taurus (Bovine) | |
| 8 | P (P) | V-type proton ATPase subunit H | polymer | 465 | 54155.9 | 1 | UniProt (F1MZL6) Pfam (PF03224) Pfam (PF11698) UniProt (by SIFTS) (O46563) | Bos taurus (Bovine) | |
| 9 | Q (a) | V-type proton ATPase subunit a | polymer | 838 | 96431.4 | 1 | UniProt (F1MJV0) Pfam (PF01496) UniProt (by SIFTS) (Q29466) | Bos taurus (Bovine) | |
| 10 | R (b) | V-type proton ATPase 21 kDa proteolipid subunit | polymer | 205 | 21530.4 | 1 | UniProt (Q2TA24) Pfam (PF00137) | Bos taurus (Bovine) | V-ATPase 21 kDa proteolipid subunit,Vacuolar proton pump 21 kDa proteolipid subunit |
| 11 | S (d) | V-type proton ATPase subunit d 1 | polymer | 351 | 40369.9 | 1 | UniProt (P61420) Pfam (PF01992) | Bos taurus (Bovine) | V-ATPase subunit d 1,32 kDa accessory protein,P39,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,Vacuolar proton pump subunit d 1 |
| 12 | T (e) | V-type proton ATPase subunit e 2 | polymer | 81 | 9189.0 | 1 | UniProt (Q2KIB5) Pfam (PF05493) | Bos taurus (Bovine) | V-ATPase subunit e 2,Vacuolar proton pump subunit e 2 |
| 13 | U (s) | V-type proton ATPase subunit S1 | polymer | 468 | 51818.8 | 1 | UniProt (P40682) Pfam (PF05827) Pfam (PF20520) | Bos taurus (Bovine) | V-ATPase subunit S1,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1 |
| 14 | V (r) | Renin receptor | polymer | 351 | 39529.3 | 1 | UniProt (P81134) Pfam (PF25294) Pfam (PF07850) | Bos taurus (Bovine) | ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,Renin/prorenin receptor,Vacuolar ATP synthase membrane sector-associated protein M8-9,V-ATPase M8.9 subunit |
| 15 | AA, BA, CA, DA, EA... (c, g, k, l, m...) | V-type proton ATPase 16 kDa proteolipid subunit | polymer | 155 | 15727.7 | 9 | UniProt (P23956) Pfam (PF00137) | Bos taurus (Bovine) | V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit |
| 16 | FA (f) | Ribonuclease kappa | polymer | 98 | 11030.0 | 1 | UniProt (Q3ZC23) Pfam (PF23489) | Bos taurus (Bovine) | RNase kappa |
| 17 | GA (t) | alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-alpha-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G44289EY) | |||
| 18 | HA (Q) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose | branched | 342.3 | 1 | In PDB GlyTouCan (G77384RA) | |||
| 19 | IA (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 20 | JA (C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 21 | KA (a) | methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate | non-polymer | 534.6 | 1 | Chemie (WJP) PubChem (155804591) | |||
| 22 | CB, LA, MA, NA, OA... (l, b, s, r) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 8 | Chemie (POV) PubChem (65167) PubChem (168614) PubChem (6070971) PubChem (5497103) PubChem (6436017) PubChem (6506401) PubChem (10908846) | |||
| 23 | PA, QA, RA, SA, TA... (s) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 24 | ZA (r) | OLEIC ACID | non-polymer | 282.5 | 1 | Chemie (OLA) PubChem (965) PubChem (445639) PubChem (637517) | |||
| 25 | AB, BB, DB, EB, FB... (g, l, m, o, p) | (5R)-2,4-dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9R,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-D-threo-pentopyranose | non-polymer | 622.8 | 6 | Chemie (WEV) PubChem (16759598) PubChem (16760033) PubChem (2287) PubChem (22524674) PubChem (24812816) PubChem (16760308) PubChem (44634695) PubChem (72947) PubChem (21159502) PubChem (23975129) PubChem (24870922) PubChem (52947790) PubChem (44119935) PubChem (71299752) PubChem (53321987) PubChem (73265348) PubChem (57792665) PubChem (59866780) PubChem (71046195) PubChem (71308159) PubChem (71668406) PubChem (73951098) PubChem (90479784) PubChem (90656913) PubChem (91333159) PubChem (94232247) PubChem (99719282) PubChem (99719280) PubChem (5353429) PubChem (5385089) PubChem (117059119) PubChem (5458921) PubChem (5702538) PubChem (6375210) PubChem (6436223) PubChem (122361934) PubChem (124081954) PubChem (124490403) PubChem (125040765) PubChem (131863036) PubChem (6610280) PubChem (99719281) PubChem (9960729) PubChem (9986395) PubChem (137521726) PubChem (138404419) PubChem (11039423) PubChem (139211178) PubChem (13375088) PubChem (124524084) PubChem (11467721) PubChem (125040764) PubChem (125040766) PubChem (125040767) PubChem (155817677) PubChem (155971306) PubChem (162981175) PubChem (125182885) PubChem (166632465) PubChem (166639048) PubChem (170922383) PubChem (129012189) PubChem (133126837) PubChem (133268469) PubChem (134694634) PubChem (135601084) PubChem (138107052) PubChem (138756148) PubChem (146018879) PubChem (162981170) PubChem (162981171) PubChem (162981172) PubChem (162981173) PubChem (162981174) PubChem (162981176) PubChem (166640169) PubChem (170999728) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 32 |
| Total formula weight | 1045837.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1901.7 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 12634.6 | |
| All* | Total formula weight | 1060373.8 |
