7KHR

Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0005886	cellular_component	plasma membrane
a	0006811	biological_process	monoatomic ion transport
a	0007035	biological_process	vacuolar acidification
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0030665	cellular_component	clathrin-coated vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031410	cellular_component	cytoplasmic vesicle
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0042470	cellular_component	melanosome
a	0045851	biological_process	pH reduction
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	1902600	biological_process	proton transmembrane transport
A	0000166	molecular_function	nucleotide binding
A	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0016887	molecular_function	ATP hydrolysis activity
A	0030133	cellular_component	transport vesicle
A	0030665	cellular_component	clathrin-coated vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0036295	biological_process	cellular response to increased oxygen levels
A	0042592	biological_process	homeostatic process
A	0045851	biological_process	pH reduction
A	0046034	biological_process	ATP metabolic process
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
b	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
b	0005737	cellular_component	cytoplasm
b	0005768	cellular_component	endosome
b	0006811	biological_process	monoatomic ion transport
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016469	cellular_component	proton-transporting two-sector ATPase complex
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0031410	cellular_component	cytoplasmic vesicle
b	0033176	cellular_component	proton-transporting V-type ATPase complex
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0045851	biological_process	pH reduction
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902494	cellular_component	catalytic complex
b	1902495	cellular_component	transmembrane transporter complex
b	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0016887	molecular_function	ATP hydrolysis activity
B	0030133	cellular_component	transport vesicle
B	0030665	cellular_component	clathrin-coated vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0036295	biological_process	cellular response to increased oxygen levels
B	0042592	biological_process	homeostatic process
B	0045851	biological_process	pH reduction
B	0046034	biological_process	ATP metabolic process
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0005737	cellular_component	cytoplasm
c	0006811	biological_process	monoatomic ion transport
c	0015078	molecular_function	proton transmembrane transporter activity
c	0016020	cellular_component	membrane
c	0016469	cellular_component	proton-transporting two-sector ATPase complex
c	0030665	cellular_component	clathrin-coated vesicle membrane
c	0030672	cellular_component	synaptic vesicle membrane
c	0031410	cellular_component	cytoplasmic vesicle
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0045851	biological_process	pH reduction
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0098588	cellular_component	bounding membrane of organelle
c	1902494	cellular_component	catalytic complex
c	1902495	cellular_component	transmembrane transporter complex
c	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0016887	molecular_function	ATP hydrolysis activity
C	0030133	cellular_component	transport vesicle
C	0030665	cellular_component	clathrin-coated vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0036295	biological_process	cellular response to increased oxygen levels
C	0042592	biological_process	homeostatic process
C	0045851	biological_process	pH reduction
C	0046034	biological_process	ATP metabolic process
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0005765	cellular_component	lysosomal membrane
d	0005769	cellular_component	early endosome
d	0005813	cellular_component	centrosome
d	0006811	biological_process	monoatomic ion transport
d	0006879	biological_process	intracellular iron ion homeostasis
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0016020	cellular_component	membrane
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0030030	biological_process	cell projection organization
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0031410	cellular_component	cytoplasmic vesicle
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
d	0036295	biological_process	cellular response to increased oxygen levels
d	0042592	biological_process	homeostatic process
d	0045851	biological_process	pH reduction
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0060271	biological_process	cilium assembly
d	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0007035	biological_process	vacuolar acidification
D	0016324	cellular_component	apical plasma membrane
D	0030665	cellular_component	clathrin-coated vesicle membrane
D	0030672	cellular_component	synaptic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0042470	cellular_component	melanosome
D	0045851	biological_process	pH reduction
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0006811	biological_process	monoatomic ion transport
e	0016020	cellular_component	membrane
e	0030665	cellular_component	clathrin-coated vesicle membrane
e	0030672	cellular_component	synaptic vesicle membrane
e	0031410	cellular_component	cytoplasmic vesicle
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0045851	biological_process	pH reduction
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0007035	biological_process	vacuolar acidification
E	0016324	cellular_component	apical plasma membrane
E	0030665	cellular_component	clathrin-coated vesicle membrane
E	0030672	cellular_component	synaptic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0042470	cellular_component	melanosome
E	0045851	biological_process	pH reduction
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0004518	molecular_function	nuclease activity
f	0004519	molecular_function	endonuclease activity
f	0004521	molecular_function	RNA endonuclease activity
f	0006811	biological_process	monoatomic ion transport
f	0006897	biological_process	endocytosis
f	0006898	biological_process	receptor-mediated endocytosis
f	0012505	cellular_component	endomembrane system
f	0016787	molecular_function	hydrolase activity
f	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
f	0030665	cellular_component	clathrin-coated vesicle membrane
f	0031410	cellular_component	cytoplasmic vesicle
f	0045851	biological_process	pH reduction
f	0048388	biological_process	endosomal lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0007035	biological_process	vacuolar acidification
F	0016324	cellular_component	apical plasma membrane
F	0030665	cellular_component	clathrin-coated vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0042470	cellular_component	melanosome
F	0045851	biological_process	pH reduction
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0005737	cellular_component	cytoplasm
g	0006811	biological_process	monoatomic ion transport
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0016469	cellular_component	proton-transporting two-sector ATPase complex
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0031410	cellular_component	cytoplasmic vesicle
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0045851	biological_process	pH reduction
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0098588	cellular_component	bounding membrane of organelle
g	1902494	cellular_component	catalytic complex
g	1902495	cellular_component	transmembrane transporter complex
g	1902600	biological_process	proton transmembrane transport
G	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0015078	molecular_function	proton transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0030665	cellular_component	clathrin-coated vesicle membrane
G	0030672	cellular_component	synaptic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
G	0045851	biological_process	pH reduction
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0097401	biological_process	synaptic vesicle lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0005813	cellular_component	centrosome
H	0005929	cellular_component	cilium
H	0006811	biological_process	monoatomic ion transport
H	0007035	biological_process	vacuolar acidification
H	0016020	cellular_component	membrane
H	0030030	biological_process	cell projection organization
H	0030665	cellular_component	clathrin-coated vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0045851	biological_process	pH reduction
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0060271	biological_process	cilium assembly
H	0061512	biological_process	protein localization to cilium
H	1902600	biological_process	proton transmembrane transport
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0005768	cellular_component	endosome
I	0005829	cellular_component	cytosol
I	0006811	biological_process	monoatomic ion transport
I	0016324	cellular_component	apical plasma membrane
I	0030665	cellular_component	clathrin-coated vesicle membrane
I	0030672	cellular_component	synaptic vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0045851	biological_process	pH reduction
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0005768	cellular_component	endosome
J	0005829	cellular_component	cytosol
J	0006811	biological_process	monoatomic ion transport
J	0016324	cellular_component	apical plasma membrane
J	0030665	cellular_component	clathrin-coated vesicle membrane
J	0030672	cellular_component	synaptic vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
J	0045851	biological_process	pH reduction
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0005737	cellular_component	cytoplasm
k	0006811	biological_process	monoatomic ion transport
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0016469	cellular_component	proton-transporting two-sector ATPase complex
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0031410	cellular_component	cytoplasmic vesicle
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0045851	biological_process	pH reduction
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0098588	cellular_component	bounding membrane of organelle
k	1902494	cellular_component	catalytic complex
k	1902495	cellular_component	transmembrane transporter complex
k	1902600	biological_process	proton transmembrane transport
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0005768	cellular_component	endosome
K	0005829	cellular_component	cytosol
K	0006811	biological_process	monoatomic ion transport
K	0016324	cellular_component	apical plasma membrane
K	0030665	cellular_component	clathrin-coated vesicle membrane
K	0030672	cellular_component	synaptic vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0045851	biological_process	pH reduction
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0005737	cellular_component	cytoplasm
l	0006811	biological_process	monoatomic ion transport
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0016469	cellular_component	proton-transporting two-sector ATPase complex
l	0030665	cellular_component	clathrin-coated vesicle membrane
l	0030672	cellular_component	synaptic vesicle membrane
l	0031410	cellular_component	cytoplasmic vesicle
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0045851	biological_process	pH reduction
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	0098588	cellular_component	bounding membrane of organelle
l	1902494	cellular_component	catalytic complex
l	1902495	cellular_component	transmembrane transporter complex
l	1902600	biological_process	proton transmembrane transport
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0006811	biological_process	monoatomic ion transport
L	0016020	cellular_component	membrane
L	0030665	cellular_component	clathrin-coated vesicle membrane
L	0030672	cellular_component	synaptic vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0045851	biological_process	pH reduction
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0005737	cellular_component	cytoplasm
m	0006811	biological_process	monoatomic ion transport
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0016469	cellular_component	proton-transporting two-sector ATPase complex
m	0030665	cellular_component	clathrin-coated vesicle membrane
m	0030672	cellular_component	synaptic vesicle membrane
m	0031410	cellular_component	cytoplasmic vesicle
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0045851	biological_process	pH reduction
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	0098588	cellular_component	bounding membrane of organelle
m	1902494	cellular_component	catalytic complex
m	1902495	cellular_component	transmembrane transporter complex
m	1902600	biological_process	proton transmembrane transport
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0006811	biological_process	monoatomic ion transport
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0030672	cellular_component	synaptic vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0042470	cellular_component	melanosome
M	0045851	biological_process	pH reduction
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0097401	biological_process	synaptic vesicle lumen acidification
M	1902600	biological_process	proton transmembrane transport
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0005737	cellular_component	cytoplasm
n	0006811	biological_process	monoatomic ion transport
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0016469	cellular_component	proton-transporting two-sector ATPase complex
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0030672	cellular_component	synaptic vesicle membrane
n	0031410	cellular_component	cytoplasmic vesicle
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0045851	biological_process	pH reduction
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	0098588	cellular_component	bounding membrane of organelle
n	1902494	cellular_component	catalytic complex
n	1902495	cellular_component	transmembrane transporter complex
n	1902600	biological_process	proton transmembrane transport
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0006811	biological_process	monoatomic ion transport
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0030665	cellular_component	clathrin-coated vesicle membrane
N	0030672	cellular_component	synaptic vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0042470	cellular_component	melanosome
N	0045851	biological_process	pH reduction
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0097401	biological_process	synaptic vesicle lumen acidification
N	1902600	biological_process	proton transmembrane transport
o	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
o	0005737	cellular_component	cytoplasm
o	0006811	biological_process	monoatomic ion transport
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0016469	cellular_component	proton-transporting two-sector ATPase complex
o	0030665	cellular_component	clathrin-coated vesicle membrane
o	0030672	cellular_component	synaptic vesicle membrane
o	0031410	cellular_component	cytoplasmic vesicle
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0045851	biological_process	pH reduction
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	0098588	cellular_component	bounding membrane of organelle
o	1902494	cellular_component	catalytic complex
o	1902495	cellular_component	transmembrane transporter complex
o	1902600	biological_process	proton transmembrane transport
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0006811	biological_process	monoatomic ion transport
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0030665	cellular_component	clathrin-coated vesicle membrane
O	0030672	cellular_component	synaptic vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0042470	cellular_component	melanosome
O	0045851	biological_process	pH reduction
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0097401	biological_process	synaptic vesicle lumen acidification
O	1902600	biological_process	proton transmembrane transport
p	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
p	0005737	cellular_component	cytoplasm
p	0006811	biological_process	monoatomic ion transport
p	0015078	molecular_function	proton transmembrane transporter activity
p	0016020	cellular_component	membrane
p	0016469	cellular_component	proton-transporting two-sector ATPase complex
p	0030665	cellular_component	clathrin-coated vesicle membrane
p	0030672	cellular_component	synaptic vesicle membrane
p	0031410	cellular_component	cytoplasmic vesicle
p	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
p	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
p	0045851	biological_process	pH reduction
p	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
p	0098588	cellular_component	bounding membrane of organelle
p	1902494	cellular_component	catalytic complex
p	1902495	cellular_component	transmembrane transporter complex
p	1902600	biological_process	proton transmembrane transport
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0005829	cellular_component	cytosol
P	0006811	biological_process	monoatomic ion transport
P	0006897	biological_process	endocytosis
P	0016020	cellular_component	membrane
P	0030665	cellular_component	clathrin-coated vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0045851	biological_process	pH reduction
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
q	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
q	0005737	cellular_component	cytoplasm
q	0006811	biological_process	monoatomic ion transport
q	0015078	molecular_function	proton transmembrane transporter activity
q	0016020	cellular_component	membrane
q	0016469	cellular_component	proton-transporting two-sector ATPase complex
q	0030665	cellular_component	clathrin-coated vesicle membrane
q	0030672	cellular_component	synaptic vesicle membrane
q	0031410	cellular_component	cytoplasmic vesicle
q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
q	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
q	0045851	biological_process	pH reduction
q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
q	0098588	cellular_component	bounding membrane of organelle
q	1902494	cellular_component	catalytic complex
q	1902495	cellular_component	transmembrane transporter complex
q	1902600	biological_process	proton transmembrane transport
r	0016020	cellular_component	membrane
r	0038023	molecular_function	signaling receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
D	PRO390-SER399
A	PRO446-SER455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32764564","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P38606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"P50516","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32764564","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XBW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6XBY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"UniProtKB","id":"P21283","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P50518","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	195
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	147
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	60
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	72
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1111
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	128
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	423
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9Z1G4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q93050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9Z1G4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	186
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	10
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"32764564","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32764564","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XBY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---