7KHR

Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0005886	cellular_component	plasma membrane
a	0007035	biological_process	vacuolar acidification
a	0016020	cellular_component	membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0030665	cellular_component	clathrin-coated vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031410	cellular_component	cytoplasmic vesicle
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0042470	cellular_component	melanosome
a	0045202	cellular_component	synapse
a	0045851	biological_process	pH reduction
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	1902600	biological_process	proton transmembrane transport
A	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006879	biological_process	intracellular iron ion homeostasis
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030133	cellular_component	transport vesicle
A	0030665	cellular_component	clathrin-coated vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0036295	biological_process	cellular response to increased oxygen levels
A	0045851	biological_process	pH reduction
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
b	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016469	cellular_component	proton-transporting two-sector ATPase complex
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0031410	cellular_component	cytoplasmic vesicle
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0043231	cellular_component	intracellular membrane-bounded organelle
b	0045851	biological_process	pH reduction
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006879	biological_process	intracellular iron ion homeostasis
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0030133	cellular_component	transport vesicle
B	0030665	cellular_component	clathrin-coated vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0036295	biological_process	cellular response to increased oxygen levels
B	0045851	biological_process	pH reduction
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0015078	molecular_function	proton transmembrane transporter activity
c	0016020	cellular_component	membrane
c	0016469	cellular_component	proton-transporting two-sector ATPase complex
c	0030665	cellular_component	clathrin-coated vesicle membrane
c	0030672	cellular_component	synaptic vesicle membrane
c	0031410	cellular_component	cytoplasmic vesicle
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0043231	cellular_component	intracellular membrane-bounded organelle
c	0045202	cellular_component	synapse
c	0045851	biological_process	pH reduction
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	1902600	biological_process	proton transmembrane transport
C	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006879	biological_process	intracellular iron ion homeostasis
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0030133	cellular_component	transport vesicle
C	0030665	cellular_component	clathrin-coated vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0036295	biological_process	cellular response to increased oxygen levels
C	0045851	biological_process	pH reduction
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0005764	cellular_component	lysosome
d	0005765	cellular_component	lysosomal membrane
d	0005769	cellular_component	early endosome
d	0005813	cellular_component	centrosome
d	0006879	biological_process	intracellular iron ion homeostasis
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0016020	cellular_component	membrane
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0030030	biological_process	cell projection organization
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0031410	cellular_component	cytoplasmic vesicle
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
d	0036295	biological_process	cellular response to increased oxygen levels
d	0045851	biological_process	pH reduction
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0060271	biological_process	cilium assembly
d	1902600	biological_process	proton transmembrane transport
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0007035	biological_process	vacuolar acidification
D	0016324	cellular_component	apical plasma membrane
D	0030665	cellular_component	clathrin-coated vesicle membrane
D	0030672	cellular_component	synaptic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0042470	cellular_component	melanosome
D	0045202	cellular_component	synapse
D	0045851	biological_process	pH reduction
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0016020	cellular_component	membrane
e	0030665	cellular_component	clathrin-coated vesicle membrane
e	0030672	cellular_component	synaptic vesicle membrane
e	0031410	cellular_component	cytoplasmic vesicle
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0045202	cellular_component	synapse
e	0045851	biological_process	pH reduction
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0055085	biological_process	transmembrane transport
e	1902600	biological_process	proton transmembrane transport
E	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0007035	biological_process	vacuolar acidification
E	0016324	cellular_component	apical plasma membrane
E	0030665	cellular_component	clathrin-coated vesicle membrane
E	0030672	cellular_component	synaptic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0042470	cellular_component	melanosome
E	0045202	cellular_component	synapse
E	0045851	biological_process	pH reduction
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0004519	molecular_function	endonuclease activity
f	0004521	molecular_function	RNA endonuclease activity
f	0006897	biological_process	endocytosis
f	0006898	biological_process	receptor-mediated endocytosis
f	0012505	cellular_component	endomembrane system
f	0016020	cellular_component	membrane
f	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
f	0030665	cellular_component	clathrin-coated vesicle membrane
f	0031410	cellular_component	cytoplasmic vesicle
f	0045851	biological_process	pH reduction
f	0048388	biological_process	endosomal lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0007035	biological_process	vacuolar acidification
F	0016324	cellular_component	apical plasma membrane
F	0030665	cellular_component	clathrin-coated vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0042470	cellular_component	melanosome
F	0045202	cellular_component	synapse
F	0045851	biological_process	pH reduction
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0016469	cellular_component	proton-transporting two-sector ATPase complex
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0031410	cellular_component	cytoplasmic vesicle
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0043231	cellular_component	intracellular membrane-bounded organelle
g	0045202	cellular_component	synapse
g	0045851	biological_process	pH reduction
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	1902600	biological_process	proton transmembrane transport
G	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
G	0005886	cellular_component	plasma membrane
G	0015078	molecular_function	proton transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0030665	cellular_component	clathrin-coated vesicle membrane
G	0030672	cellular_component	synaptic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
G	0045202	cellular_component	synapse
G	0045851	biological_process	pH reduction
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005856	cellular_component	cytoskeleton
H	0005929	cellular_component	cilium
H	0016020	cellular_component	membrane
H	0030030	biological_process	cell projection organization
H	0030665	cellular_component	clathrin-coated vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0042995	cellular_component	cell projection
H	0045851	biological_process	pH reduction
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0060271	biological_process	cilium assembly
H	0061512	biological_process	protein localization to cilium
H	1902600	biological_process	proton transmembrane transport
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0005768	cellular_component	endosome
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0016324	cellular_component	apical plasma membrane
I	0030665	cellular_component	clathrin-coated vesicle membrane
I	0030672	cellular_component	synaptic vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0045202	cellular_component	synapse
I	0045851	biological_process	pH reduction
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0005768	cellular_component	endosome
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0016324	cellular_component	apical plasma membrane
J	0030665	cellular_component	clathrin-coated vesicle membrane
J	0030672	cellular_component	synaptic vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
J	0045202	cellular_component	synapse
J	0045851	biological_process	pH reduction
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0016469	cellular_component	proton-transporting two-sector ATPase complex
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0031410	cellular_component	cytoplasmic vesicle
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0043231	cellular_component	intracellular membrane-bounded organelle
k	0045202	cellular_component	synapse
k	0045851	biological_process	pH reduction
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	1902600	biological_process	proton transmembrane transport
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0005768	cellular_component	endosome
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0016324	cellular_component	apical plasma membrane
K	0030665	cellular_component	clathrin-coated vesicle membrane
K	0030672	cellular_component	synaptic vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0045202	cellular_component	synapse
K	0045851	biological_process	pH reduction
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0016469	cellular_component	proton-transporting two-sector ATPase complex
l	0030665	cellular_component	clathrin-coated vesicle membrane
l	0030672	cellular_component	synaptic vesicle membrane
l	0031410	cellular_component	cytoplasmic vesicle
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0043231	cellular_component	intracellular membrane-bounded organelle
l	0045202	cellular_component	synapse
l	0045851	biological_process	pH reduction
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	1902600	biological_process	proton transmembrane transport
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0016020	cellular_component	membrane
L	0030665	cellular_component	clathrin-coated vesicle membrane
L	0030672	cellular_component	synaptic vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0045202	cellular_component	synapse
L	0045851	biological_process	pH reduction
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0016469	cellular_component	proton-transporting two-sector ATPase complex
m	0030665	cellular_component	clathrin-coated vesicle membrane
m	0030672	cellular_component	synaptic vesicle membrane
m	0031410	cellular_component	cytoplasmic vesicle
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0043231	cellular_component	intracellular membrane-bounded organelle
m	0045202	cellular_component	synapse
m	0045851	biological_process	pH reduction
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	1902600	biological_process	proton transmembrane transport
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0016020	cellular_component	membrane
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0016887	molecular_function	ATP hydrolysis activity
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0030672	cellular_component	synaptic vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0042470	cellular_component	melanosome
M	0045851	biological_process	pH reduction
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0097401	biological_process	synaptic vesicle lumen acidification
M	1902600	biological_process	proton transmembrane transport
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0016469	cellular_component	proton-transporting two-sector ATPase complex
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0030672	cellular_component	synaptic vesicle membrane
n	0031410	cellular_component	cytoplasmic vesicle
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0043231	cellular_component	intracellular membrane-bounded organelle
n	0045202	cellular_component	synapse
n	0045851	biological_process	pH reduction
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	1902600	biological_process	proton transmembrane transport
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0016887	molecular_function	ATP hydrolysis activity
N	0030665	cellular_component	clathrin-coated vesicle membrane
N	0030672	cellular_component	synaptic vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0042470	cellular_component	melanosome
N	0045851	biological_process	pH reduction
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0097401	biological_process	synaptic vesicle lumen acidification
N	1902600	biological_process	proton transmembrane transport
o	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0016469	cellular_component	proton-transporting two-sector ATPase complex
o	0030665	cellular_component	clathrin-coated vesicle membrane
o	0030672	cellular_component	synaptic vesicle membrane
o	0031410	cellular_component	cytoplasmic vesicle
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0043231	cellular_component	intracellular membrane-bounded organelle
o	0045202	cellular_component	synapse
o	0045851	biological_process	pH reduction
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	1902600	biological_process	proton transmembrane transport
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0016020	cellular_component	membrane
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0016887	molecular_function	ATP hydrolysis activity
O	0030665	cellular_component	clathrin-coated vesicle membrane
O	0030672	cellular_component	synaptic vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0042470	cellular_component	melanosome
O	0045851	biological_process	pH reduction
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0097401	biological_process	synaptic vesicle lumen acidification
O	1902600	biological_process	proton transmembrane transport
p	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
p	0015078	molecular_function	proton transmembrane transporter activity
p	0016020	cellular_component	membrane
p	0016469	cellular_component	proton-transporting two-sector ATPase complex
p	0030665	cellular_component	clathrin-coated vesicle membrane
p	0030672	cellular_component	synaptic vesicle membrane
p	0031410	cellular_component	cytoplasmic vesicle
p	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
p	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
p	0043231	cellular_component	intracellular membrane-bounded organelle
p	0045202	cellular_component	synapse
p	0045851	biological_process	pH reduction
p	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
p	1902600	biological_process	proton transmembrane transport
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0016020	cellular_component	membrane
P	0030665	cellular_component	clathrin-coated vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0045851	biological_process	pH reduction
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
q	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
q	0015078	molecular_function	proton transmembrane transporter activity
q	0016020	cellular_component	membrane
q	0016469	cellular_component	proton-transporting two-sector ATPase complex
q	0030665	cellular_component	clathrin-coated vesicle membrane
q	0030672	cellular_component	synaptic vesicle membrane
q	0031410	cellular_component	cytoplasmic vesicle
q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
q	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
q	0043231	cellular_component	intracellular membrane-bounded organelle
q	0045202	cellular_component	synapse
q	0045851	biological_process	pH reduction
q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
q	1902600	biological_process	proton transmembrane transport
r	0016020	cellular_component	membrane
r	0038023	molecular_function	signaling receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
D	PRO390-SER399
A	PRO446-SER455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	510
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
a	MET1-GLU388
l	MET1-TYR10
l	ALA77-GLN92
l	SER153-LYS155
m	MET1-TYR10
m	ALA77-GLN92
m	SER153-LYS155
n	MET1-TYR10
n	ALA77-GLN92
n	SER153-LYS155
o	MET1-TYR10
a	GLU427-SER441
o	ALA77-GLN92
o	SER153-LYS155
p	MET1-TYR10
p	ALA77-GLN92
p	SER153-LYS155
q	MET1-TYR10
q	ALA77-GLN92
q	SER153-LYS155
a	SER556-PHE573
a	ARG660-THR725
a	PHE811-ASP838
g	SER153-LYS155
k	MET1-TYR10
k	ALA77-GLN92
k	SER153-LYS155

---

site_id	SWS_FT_FI2
Number of Residues	183
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
a	ILE389-PHE407
k	ILE56-ILE76
k	LEU93-GLY114
k	ILE132-LEU152
l	ALA11-GLY33
l	ILE56-ILE76
l	LEU93-GLY114
l	ILE132-LEU152
m	ALA11-GLY33
m	ILE56-ILE76
m	LEU93-GLY114
a	LEU410-ARG426
m	ILE132-LEU152
n	ALA11-GLY33
n	ILE56-ILE76
n	LEU93-GLY114
n	ILE132-LEU152
o	ALA11-GLY33
o	ILE56-ILE76
o	LEU93-GLY114
o	ILE132-LEU152
p	ALA11-GLY33
a	THR442-SER471
p	ILE56-ILE76
p	LEU93-GLY114
p	ILE132-LEU152
q	ALA11-GLY33
q	ILE56-ILE76
q	LEU93-GLY114
q	ILE132-LEU152
a	PHE536-LEU555
a	ILE574-LYS594
a	LEU640-LEU659
a	ILE726-ALA750
a	GLY772-GLU810
k	ALA11-GLY33

---

site_id	SWS_FT_FI3
Number of Residues	128
Details	TOPO_DOM: Vacuolar => ECO:0000255

Chain	Residue	Details
a	GLY408-ASP409
m	ASP115-MET131
n	THR34-SER55
n	ASP115-MET131
o	THR34-SER55
o	ASP115-MET131
p	THR34-SER55
p	ASP115-MET131
q	THR34-SER55
q	ASP115-MET131
a	LEU472-SER535
a	TRP595-PHE639
a	GLN751-ALA771
k	THR34-SER55
k	ASP115-MET131
l	THR34-SER55
l	ASP115-MET131
m	THR34-SER55

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9Z1G4

Chain	Residue	Details
a	THR250
r	THR278
k	GLU139
l	GLU139
m	GLU139
n	GLU139
o	GLU139
p	GLU139
q	GLU139

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q93050

Chain	Residue	Details
a	THR360
s	ASN258

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1G4

Chain	Residue	Details
a	TYR364
s	ASN294
s	ASN301
s	ASN348
s	ASN355
s	ASN404

---