7KD6
Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, H, N, T | Single-chain Insulin SCI-b | polymer | 57 | 6515.3 | 4 | Pfam (PF00049) UniProt (by SIFTS) (P01308) In PDB | Homo sapiens | |
| 2 | C, I, O, U | Fv 83-7 Heavy chain | polymer | 126 | 13655.3 | 4 | Mus musculus | ||
| 3 | D, J, P, V | Fv 83-7 Light chain | polymer | 121 | 13367.9 | 4 | Mus musculus | ||
| 4 | E, K, Q, W | Insulin receptor subunit alpha | polymer | 317 | 36231.8 | 4 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) In PDB | Homo sapiens (Human) | IR |
| 5 | F, L, R, X | Insulin receptor isoform A alphaCT peptide | polymer | 16 | 1922.1 | 4 | UniProt (by SIFTS) (P06213) In PDB | Homo sapiens | |
| 6 | Y, Z, 1, M, S | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 5 | In PDB GlyTouCan (G32152BH) | |||
| 7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 8 | 3, 4, G, 2 | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 9 | C, I, O, U | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 10 | D | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 11 | E, K, Q, W | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 12 | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
E, K, Q, W: 1 - 310 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| Ser 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Val 315 | - | expression tag |
| Pro 316 | - | expression tag |
| Arg 317 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 286769.6 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5931.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2688.4 | |
| All* | Total formula weight | 295389.6 |
