7JL3
Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Antiviral innate immune response receptor RIG-I | polymer | 722 | 82724.1 | 3 | UniProt (O95786) Pfam (PF00270) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) | Homo sapiens (Human) | DEAD box protein 58,Probable ATP-dependent RNA helicase DDX58,RIG-I-like receptor 1,RLR-1,Retinoic acid-inducible gene 1 protein,RIG-1,Retinoic acid-inducible gene I protein,RIG-I |
| 2 | B, D, F (B, D, F) | E3 ubiquitin-protein ligase RNF135 | polymer | 184 | 21021.9 | 3 | UniProt (Q8IUD6) Pfam (PF00622) | Homo sapiens (Human) | RIG-I E3 ubiquitin ligase,REUL,RING finger protein 135,RING finger protein leading to RIG-I activation,Riplet,RING-type E3 ubiquitin transferase RNF135 |
| 3 | G (X) | dsRNA strand1 | polymer | 42 | 13550.1 | 1 | Homo sapiens | ||
| 4 | H (Y) | dsRNA strand 2 | polymer | 42 | 13360.9 | 1 | Homo sapiens | ||
| 5 | I, M, Q (A, C, E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 6 | J, N, R (A, C, E) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 3 | Chemie (ALF) | |||
| 7 | K, O, S (A, C, E) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 8 | L, P, T (A, C, E) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 338148.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1859.7 | |
| All* | Total formula weight | 340008.6 |
