7JL2
Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | X | RNA (44-MER) | polymer | 44 | 14208.5 | 1 | Homo sapiens | ||
2 | Y | RNA (44-MER) | polymer | 44 | 13973.2 | 1 | Homo sapiens | ||
3 | A, C, E | Interferon-induced helicase C domain-containing protein 1 | polymer | 739 | 84901.7 | 3 | UniProt (Q9BYX4) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) In PDB | Homo sapiens (Human) | Clinically amyopathic dermatomyositis autoantigen 140 kDa,CADM-140 autoantigen,Helicase with 2 CARD domains,Helicard,Interferon-induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,Murabutide down-regulated protein,RIG-I-like receptor 2,RLR-2,RNA helicase-DEAD box protein 116,IFIH1 |
4 | B, D, F | Tripartite motif-containing protein 65 | polymer | 191 | 21643.4 | 3 | UniProt (Q6PJ69) Pfam (PF00622) In PDB | Homo sapiens (Human) | TRIM65 |
5 | A, C, E | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
6 | A, C, E | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
7 | A, C, E | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 3 | Chemie (ALF) | |||
8 | A, C, E | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) |
Sequence modifications
A, C, E: 287 - 1025 (UniProt: Q9BYX4)
B, D, F: 312 - 502 (UniProt: Q6PJ69)
PDB | External Database | Details |
---|---|---|
Arg 843 | His 843 | conflict |
Lys 944 | Asn 944 | conflict |
Thr 946 | Ala 946 | conflict |
PDB | External Database | Details |
---|---|---|
Leu 356 | Cys 356 | conflict |
Ser 407 | Cys 407 | conflict |
Ser 421 | Cys 421 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 347816.9 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1859.7 | |
All* | Total formula weight | 349676.6 |