7JL2
Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016787 | molecular_function | hydrolase activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0016787 | molecular_function | hydrolase activity |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0016787 | molecular_function | hydrolase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01125 |
| Chain | Residue | Details |
| A | CYS907 | |
| E | CYS910 | |
| E | CYS962 | |
| E | CYS964 | |
| A | CYS910 | |
| A | CYS962 | |
| A | CYS964 | |
| C | CYS907 | |
| C | CYS910 | |
| C | CYS962 | |
| C | CYS964 | |
| E | CYS907 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R5F7 |
| Chain | Residue | Details |
| A | SER289 | |
| E | SER291 | |
| E | SER301 | |
| E | SER645 | |
| A | SER291 | |
| A | SER301 | |
| A | SER645 | |
| C | SER289 | |
| C | SER291 | |
| C | SER301 | |
| C | SER645 | |
| E | SER289 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by RIOK3 => ECO:0000269|PubMed:25865883 |
| Chain | Residue | Details |
| A | SER828 | |
| C | SER828 | |
| E | SER828 |
