7JIC

Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	B-lymphocyte antigen CD19	polymer	323	36031.6	1	UniProt (P15391)	Homo sapiens (Human)	B-lymphocyte surface antigen B4,Differentiation antigen CD19,T-cell surface antigen Leu-12
2	B (B)	CD81 antigen	polymer	247	26444.8	1	UniProt (P60033) Pfam (PF00335)	Homo sapiens (Human)	26 kDa cell surface protein TAPA-1,Target of the antiproliferative antibody 1,Tetraspanin-28,Tspan-28
3	C (H)	Coltuximab Heavy Chain	polymer	233	24828.6	1		Mus musculus (Mouse)
4	D (L)	Coltuximab Light Chain	polymer	213	23211.8	1		Mus musculus (Mouse)

Sequence modifications

A: 20 - 323 (UniProt: P15391)

PDB	External Database	Details
Asp 5	-	expression tag
Tyr 6	-	expression tag
Lys 7	-	expression tag
Asp 8	-	expression tag
Asp 9	-	expression tag
Asp 10	-	expression tag
Asp 11	-	expression tag
Leu 12	-	expression tag
Glu 13	-	expression tag
Val 14	-	expression tag
Leu 15	-	expression tag
Phe 16	-	expression tag
Gln 17	-	expression tag
Gly 18	-	expression tag
Pro 19	-	expression tag

B: 2 - 236 (UniProt: P60033)

PDB	External Database	Details
Gly -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Thr 171	Lys 171	conflict
Ser 172	Asn 172	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	110516.7
All*	Total formula weight	110516.7

*Water molecules are not included.