7JIC
Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | B-lymphocyte antigen CD19 | polymer | 323 | 36031.6 | 1 | UniProt (P15391) In PDB | Homo sapiens (Human) | B-lymphocyte surface antigen B4,Differentiation antigen CD19,T-cell surface antigen Leu-12 |
2 | B | CD81 antigen | polymer | 247 | 26444.8 | 1 | UniProt (P60033) Pfam (PF00335) In PDB | Homo sapiens (Human) | 26 kDa cell surface protein TAPA-1,Target of the antiproliferative antibody 1,Tetraspanin-28,Tspan-28 |
3 | H | Coltuximab Heavy Chain | polymer | 233 | 24828.6 | 1 | Mus musculus (Mouse) | ||
4 | L | Coltuximab Light Chain | polymer | 213 | 23211.8 | 1 | Mus musculus (Mouse) |
Sequence modifications
A: 20 - 323 (UniProt: P15391)
B: 2 - 236 (UniProt: P60033)
PDB | External Database | Details |
---|---|---|
Asp 5 | - | expression tag |
Tyr 6 | - | expression tag |
Lys 7 | - | expression tag |
Asp 8 | - | expression tag |
Asp 9 | - | expression tag |
Asp 10 | - | expression tag |
Asp 11 | - | expression tag |
Leu 12 | - | expression tag |
Glu 13 | - | expression tag |
Val 14 | - | expression tag |
Leu 15 | - | expression tag |
Phe 16 | - | expression tag |
Gln 17 | - | expression tag |
Gly 18 | - | expression tag |
Pro 19 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Gly -6 | - | expression tag |
Ser -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Gly -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
Thr 171 | Lys 171 | conflict |
Ser 172 | Asn 172 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 110516.7 | |
All* | Total formula weight | 110516.7 |