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7JIC

Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0002322biological_processB cell proliferation involved in immune response
A0050864biological_processregulation of B cell activation
B0001618molecular_functionvirus receptor activity
B0001771biological_processimmunological synapse formation
B0001772cellular_componentimmunological synapse
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0002455biological_processhumoral immune response mediated by circulating immunoglobulin
B0002863biological_processpositive regulation of inflammatory response to antigenic stimulus
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0008289molecular_functionlipid binding
B0009925cellular_componentbasal plasma membrane
B0014905biological_processmyoblast fusion involved in skeletal muscle regeneration
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0023026molecular_functionMHC class II protein complex binding
B0030890biological_processpositive regulation of B cell proliferation
B0031623biological_processreceptor internalization
B0031647biological_processregulation of protein stability
B0031982cellular_componentvesicle
B0034238biological_processmacrophage fusion
B0035783biological_processCD4-positive, alpha-beta T cell costimulation
B0042127biological_processregulation of cell population proliferation
B0042289molecular_functionMHC class II protein binding
B0043410biological_processpositive regulation of MAPK cascade
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046718biological_processsymbiont entry into host cell
B0050861biological_processpositive regulation of B cell receptor signaling pathway
B0050862biological_processpositive regulation of T cell receptor signaling pathway
B0050871biological_processpositive regulation of B cell activation
B0061462biological_processprotein localization to lysosome
B0070062cellular_componentextracellular exosome
B0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0072659biological_processprotein localization to plasma membrane
B0072675biological_processosteoclast fusion
B0097197cellular_componenttetraspanin-enriched microdomain
B1903911biological_processpositive regulation of receptor clustering
B1904352biological_processpositive regulation of protein catabolic process in the vacuole
B1905521biological_processregulation of macrophage migration
B1905676biological_processpositive regulation of adaptive immune memory response
B1990459molecular_functiontransferrin receptor binding
B2000553biological_processpositive regulation of T-helper 2 cell cytokine production
B2000563biological_processpositive regulation of CD4-positive, alpha-beta T cell proliferation
B2001190biological_processpositive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR191-HIS197
HTYR200-HIS206

site_idPS00421
Number of Residues23
DetailsTM4_1 Transmembrane 4 family signature. GavmMfvGFLGCyGAiqEsqCLL
ChainResidueDetails
BGLY69-LEU91

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P25918","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29490423","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AL5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues64
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27881302","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues29
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27881302","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27881302","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TCX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"27993971","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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