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7JIC

Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment

Functional Information from GO Data
ChainGOidnamespacecontents
A0002322biological_processB cell proliferation involved in immune response
A0050864biological_processregulation of B cell activation
B0001618molecular_functionvirus receptor activity
B0001771biological_processimmunological synapse formation
B0001772cellular_componentimmunological synapse
B0002250biological_processadaptive immune response
B0002455biological_processhumoral immune response mediated by circulating immunoglobulin
B0002863biological_processpositive regulation of inflammatory response to antigenic stimulus
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0008289molecular_functionlipid binding
B0009925cellular_componentbasal plasma membrane
B0014905biological_processmyoblast fusion involved in skeletal muscle regeneration
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0023026molecular_functionMHC class II protein complex binding
B0030890biological_processpositive regulation of B cell proliferation
B0031623biological_processreceptor internalization
B0031647biological_processregulation of protein stability
B0031982cellular_componentvesicle
B0034238biological_processmacrophage fusion
B0035783biological_processCD4-positive, alpha-beta T cell costimulation
B0042289molecular_functionMHC class II protein binding
B0043410biological_processpositive regulation of MAPK cascade
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046718biological_processsymbiont entry into host cell
B0050861biological_processpositive regulation of B cell receptor signaling pathway
B0050862biological_processpositive regulation of T cell receptor signaling pathway
B0050871biological_processpositive regulation of B cell activation
B0061462biological_processprotein localization to lysosome
B0070062cellular_componentextracellular exosome
B0070863biological_processpositive regulation of protein exit from endoplasmic reticulum
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0072659biological_processprotein localization to plasma membrane
B0072675biological_processosteoclast fusion
B0097197cellular_componenttetraspanin-enriched microdomain
B1903911biological_processpositive regulation of receptor clustering
B1904352biological_processpositive regulation of protein catabolic process in the vacuole
B1905521biological_processregulation of macrophage migration
B1905676biological_processpositive regulation of adaptive immune memory response
B1990459molecular_functiontransferrin receptor binding
B2000145biological_processregulation of cell motility
B2000553biological_processpositive regulation of T-helper 2 cell cytokine production
B2000563biological_processpositive regulation of CD4-positive, alpha-beta T cell proliferation
B2001190biological_processpositive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Functional Information from PROSITE/UniProt
site_idPS00421
Number of Residues23
DetailsTM4_1 Transmembrane 4 family signature. GavmMfvGFLGCyGAiqEsqCLL
ChainResidueDetails
BGLY69-LEU91

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR191-HIS197
HTYR200-HIS206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:27881302
ChainResidueDetails
BLEU13-LEU33
BILE64-ILE84
BLEU90-GLY112
BLEU202-MET224

site_idSWS_FT_FI2
Number of Residues117
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:27881302
ChainResidueDetails
BTRP34-TYR63
BPHE113-LYS201

site_idSWS_FT_FI3
Number of Residues4
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27881302
ChainResidueDetails
BGLN85-CYS89

site_idSWS_FT_FI4
Number of Residues11
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27881302, ECO:0000305|PubMed:1860863
ChainResidueDetails
BVAL225-TYR236
AASN125

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:27881302, ECO:0007744|PDB:5TCX
ChainResidueDetails
BGLU219
AASN181
AASN265

site_idSWS_FT_FI6
Number of Residues3
DetailsSITE: Important for interaction with integrin => ECO:0000269|PubMed:27993971
ChainResidueDetails
BLYS116
BLYS144
BLYS148

219140

PDB entries from 2024-05-01

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