7JHP
Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of CRaf-kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase HRas | polymer | 166 | 18821.1 | 1 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (Human) | H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras |
| 2 | B (C) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 133 | 15364.0 | 1 | UniProt (P04049) Pfam (PF02196) Pfam (PF00130) | Homo sapiens (Human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E, F (C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | G, H (A, C) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Cys 97 | Arg 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34185.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 677.3 | |
| All* | Total formula weight | 34862.5 |
