7JHP

Crystal structure of HRas in complex with the Ras-binding and cysteine-rich domains of CRaf-kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
C	0007165	biological_process	signal transduction

Functional Information from PROSITE/UniProt

site_id	PS00479
Number of Residues	46
Details	ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFarktflklaf.CdiCqkfLlngfr.....CqtCgykfHehCstkvptm..C

Chain	Residue	Details
C	HIS139-CYS184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	ZN_FING: Phorbol-ester/DAG-type => ECO:0000255|PROSITE-ProRule:PRU00226

Chain	Residue	Details
C	THR138-CYS184
A	VAL29
A	ALA59
A	ASN116
A	SER145

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
C	HIS139
C	CYS152
C	CYS155
C	CYS165
C	CYS168
C	HIS173
C	CYS176
C	CYS184

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12

Chain	Residue	Details
A	THR2

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151

Chain	Residue	Details
A	CYS118

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667

Chain	Residue	Details
A	THR35

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