7FCP
Crystallographic structure of two neutralizing antibodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spike protein S1 | polymer | 277 | 30940.7 | 1 | UniProt (P0DTC2) Pfam (PF09408) Pfam (PF19209) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 2 | B (H) | P14-44 antibody Fab fragment heavy chain | polymer | 235 | 25477.5 | 1 | Homo sapiens | ||
| 3 | C (L) | P14-44 antibody Fab fragment light chain | polymer | 216 | 22858.2 | 1 | Homo sapiens | ||
| 4 | D (B) | P5-22 antibody Fab fragment heavy chain | polymer | 227 | 24304.2 | 1 | Homo sapiens | ||
| 5 | E (D) | P5-22 antibody Fab fragment light chain | polymer | 214 | 23547.1 | 1 | Homo sapiens | ||
| 6 | F (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 7 | G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | H, I (H, D) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 9 | J, K, L, M, N (A, H, L, B, D) | water | water | 18.0 | 589 | Chemie (HOH) |
Sequence modifications
A: 321 - 591 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Val 319 | - | expression tag |
| Asp 320 | - | expression tag |
| Ser 592 | - | expression tag |
| Arg 593 | - | expression tag |
| Gly 594 | - | expression tag |
| Ser 595 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 127127.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 527.5 | |
| All* | Total formula weight | 127655.1 |
