7F1T

Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5	polymer	491	55445.5	1	UniProt (P10147) UniProt (P51681) UniProt (P00268) Pfam (PF00048) Pfam (PF00001) Pfam (PF00301) In PDB	Homo sapiens (Human)	G0/G1 switch regulatory protein 19-1,Macrophage inflammatory protein 1-alpha,MIP-1-alpha,PAT 464.1,SIS-beta,Small-inducible cytokine A3,Tonsillar lymphocyte LD78 alpha protein,C-C CKR-5,CC-CKR-5,CCR-5,CCR5,CHEMR13,HIV-1 fusion coreceptor,Rd
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: -95 - -27 (UniProt: P10147)

PDB	External Database	Details
Cys -81	Thr 38	engineered mutation
Gly -22	-	linker
Ser -21	-	linker
Gly -20	-	linker
Ser -19	-	linker
Gly -18	-	linker
Ser -17	-	linker
Gly -16	-	linker
Ser -15	-	linker
Gly -14	-	linker
Ser -13	-	linker
Gly -12	-	linker
Ser -11	-	linker
Gly -10	-	linker
Ser -9	-	linker
Gly -8	-	linker
Ser -7	-	linker
Gly -6	-	linker
Ser -5	-	linker
Gly -4	-	linker
Ser -3	-	linker
Gly -2	-	linker
Ser -1	-	linker
Gly 0	-	linker
Ser 1	-	linker

A: 2 - 223 (UniProt: P51681)

PDB	External Database	Details
Cys 16	Thr 16	engineered mutation
Tyr 58	Cys 58	engineered mutation
Ala 64	Met 64	engineered mutation
Asn 163	Gly 163	engineered mutation

A: 1001 - 1054 (UniProt: P00268)
A: 227 - 319 (UniProt: P51681)

PDB	External Database	Details
Asp 233	Ala 233	engineered mutation
Ala 274	Arg 274	engineered mutation
Ala 284	Thr 284	engineered mutation
Glu 303	Lys 303	engineered mutation
Gly 320	-	expression tag
Arg 321	-	expression tag
Pro 322	-	expression tag
Leu 323	-	expression tag
Glu 324	-	expression tag
Val 325	-	expression tag
Leu 326	-	expression tag
Phe 327	-	expression tag
Gln 328	-	expression tag
Gly 329	-	expression tag
Pro 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
Asp 341	-	expression tag
Tyr 342	-	expression tag
Lys 343	-	expression tag
Asp 344	-	expression tag
Asp 345	-	expression tag
Asp 346	-	expression tag
Asp 347	-	expression tag
Lys 348	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55445.5
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	55510.9

*Water molecules are not included.