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7F1T

Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0001649biological_processosteoblast differentiation
A0001775biological_processcell activation
A0002548biological_processmonocyte chemotaxis
A0004672molecular_functionprotein kinase activity
A0004930molecular_functionG protein-coupled receptor activity
A0005125molecular_functioncytokine activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006887biological_processexocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007010biological_processcytoskeleton organization
A0007186biological_processG protein-coupled receptor signaling pathway
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0008360biological_processregulation of cell shape
A0009055molecular_functionelectron transfer activity
A0009636biological_processresponse to toxic substance
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010818biological_processT cell chemotaxis
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0016004molecular_functionphospholipase activator activity
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0019722biological_processcalcium-mediated signaling
A0023052biological_processsignaling
A0030335biological_processpositive regulation of cell migration
A0030502biological_processnegative regulation of bone mineralization
A0030593biological_processneutrophil chemotaxis
A0031726molecular_functionCCR1 chemokine receptor binding
A0031730molecular_functionCCR5 chemokine receptor binding
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0042056molecular_functionchemoattractant activity
A0042802molecular_functionidentical protein binding
A0043308biological_processeosinophil degranulation
A0043448biological_processalkane catabolic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043615biological_processastrocyte cell migration
A0043922biological_processhost-mediated suppression of viral transcription
A0045671biological_processnegative regulation of osteoclast differentiation
A0046872molecular_functionmetal ion binding
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0048246biological_processmacrophage chemotaxis
A0048247biological_processlymphocyte chemotaxis
A0050729biological_processpositive regulation of inflammatory response
A0050795biological_processregulation of behavior
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050918biological_processpositive chemotaxis
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051928biological_processpositive regulation of calcium ion transport
A0051930biological_processregulation of sensory perception of pain
A0060326biological_processcell chemotaxis
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070723biological_processresponse to cholesterol
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071621biological_processgranulocyte chemotaxis
A0090280biological_processpositive regulation of calcium ion import
A1903980biological_processpositive regulation of microglial cell activation
A1904141biological_processpositive regulation of microglial cell migration
A2000503biological_processpositive regulation of natural killer cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00202
Number of Residues11
DetailsRUBREDOXIN Rubredoxin signature. IpDDWvCPlCG
ChainResidueDetails
AILE1033-GLY1043

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIfFIILLTIDRYLaV
ChainResidueDetails
ASER114-VAL130

site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFsycsrq..IpqnfIadYfetssq..Cskp.GVIFltkrsrqv.CA
ChainResidueDetails
ACYS-86-ALA-45

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00241","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10216292","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N-formylmethionine","evidences":[{"source":"PubMed","id":"1637309","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsSite: {"description":"Involved in GAG binding"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues25
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues59
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"21763489","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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