7EZC

Adenosine A2a receptor mutant-I92N

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Adenosine receptor A2a,Soluble cytochrome b562	polymer	431	48158.9	2	UniProt (P29274) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361)	Homo sapiens (human)	Cytochrome b-562
2	C, D (A, B)	6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide	non-polymer		777.9	2	Chemie (UKA)

Sequence modifications

A, B: 2 - 208 (UniProt: P29274)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Asn 92	Ile 92	engineered mutation

A, B: 1001 - 1101 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	engineered mutation
Ile 1102	-	linker
Gln 1103	-	linker
Lys 1104	-	linker
Tyr 1105	-	linker
Leu 1106	-	linker

A, B: 219 - 308 (UniProt: P29274)

PDB	External Database	Details
Arg 309	-	expression tag
Gln 310	-	expression tag
Gln 311	-	expression tag
Glu 312	-	expression tag
Pro 313	-	expression tag
Phe 314	-	expression tag
Lys 315	-	expression tag
Ala 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96317.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1555.7
All*	Total formula weight	97873.6

*Water molecules are not included.