7EVR

Crystal structure of hnRNP L RRM2 in complex with SETD2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Heterogeneous nuclear ribonucleoprotein L	polymer	111	12626.2	2	UniProt (P14866) Pfam (PF11835)	Homo sapiens (Human)	hnRNP L
2	B, D (B, D)	SHI domain from Histone-lysine N-methyltransferase SETD2	polymer	26	2788.2	2	UniProt (Q9BYW2)	Homo sapiens	HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP
3	E, F, G, H (A, B, C, D)	water	water		18.0	332	Chemie (HOH)

Sequence modifications

A, C: 186 - 289 (UniProt: P14866)

PDB	External Database	Details
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
Met 185	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	30828.8
All*	Total formula weight	30828.8

*Water molecules are not included.