7EQ2

Crystal structure of GDP-bound Rab1a-T75D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ras-related protein Rab-1A	polymer	184	21112.9	2	UniProt (P62820) Pfam (PF00071)	Homo sapiens (human)	YPT1-related protein
2	C, H (A, B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
3	D, I (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, F, J, K (A, B)	COBALT HEXAMMINE(III)	non-polymer		161.1	4	Chemie (NCO)
5	G, L (A, B)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
6	M, N (B)	CACODYLATE ION	non-polymer		137.0	2	Chemie (CAC)
7	O, P (A, B)	water	water		18.0	372	Chemie (HOH)

Sequence modifications

A, B: 1 - 176 (UniProt: P62820)

PDB	External Database	Details
Asp 75	Thr 75	engineered mutation
Leu 177	-	expression tag
Glu 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42225.7
Non-Polymers*	Number of molecules	12
	Total formula weight	2089.8
All*	Total formula weight	44315.5

*Water molecules are not included.