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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7E2X

Apo serotonin 1A (5-HT1A) receptor-Gi protein complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440414.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (Human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P62873)
Pfam (PF25391)		Homo sapiens (Human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (Human)G gamma-I
4D
(R)		Soluble cytochrome b562,5-hydroxytryptamine receptor 1Apolymer54360408.51UniProt (P0ABE7)
UniProt (P08908)
Pfam (PF00001)		Escherichia coliCytochrome b-562,5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A
5E
(R)		[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoatenon-polymer854.91Chemie (J40)
PubChem (155884459)
PubChem (171389934)
6F, G, H, I, K...
(R)		CHOLESTEROLnon-polymer386.710Chemie (CLR)
PubChem (304)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (638019)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (16219173)
PubChem (16758052)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (176980071)
PubChem (45044259)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (49853509)
PubChem (44654663)
PubChem (46937002)
PubChem (59274407)
PubChem (50990013)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (52934537)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (56621683)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (57915018)
PubChem (57939063)
PubChem (138967089)
PubChem (58428240)
PubChem (58445498)
PubChem (139566851)
PubChem (58663286)
PubChem (15939944)
PubChem (59450329)
PubChem (59628412)
PubChem (171828367)
PubChem (173516975)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7J, Q, R
(R)		PALMITIC ACIDnon-polymer256.43Chemie (PLM)
8S
(R)		waterwater18.09Chemie (HOH)
Sequence modifications
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47engineered mutation
Ala 203Gly 203engineered mutation
Ala 245Glu 245engineered mutation
Ser 326Ala 326engineered mutation
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: -92 - 13 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Asp -120-expression tag
Tyr -119-expression tag
Lys -118-expression tag
Asp -117-expression tag
Asp -116-expression tag
Asp -115-expression tag
Asp -114-expression tag
Ala -113-expression tag
Lys -112-expression tag
Leu -111-expression tag
Gln -110-expression tag
Thr -109-expression tag
Met -108-expression tag
His -107-expression tag
His -106-expression tag
His -105-expression tag
His -104-expression tag
His -103-expression tag
His -102-expression tag
His -101-expression tag
His -100-expression tag
His -99-expression tag
His -98-expression tag
His -97-expression tag
His -96-expression tag
His -95-expression tag
His -94-expression tag
His -93-expression tag
Trp -86Met 29engineered mutation
Ile 9His 124engineered mutation
Leu 13Arg 128engineered mutation
Ala 14-linker
Ser 15-linker
Glu 16-linker
Asn 17-linker
Leu 18-linker
Tyr 19-linker
Phe 20-linker
Gln 21-linker
Gly 22-linker
Gly 23-linker
Thr 24-linker
R: 25 - 422 (UniProt: P08908)
PDBExternal DatabaseDetails
Trp 125Leu 125engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight146599.2
Non-Polymers*Number of molecules14
Total formula weight5490.7
All*Total formula weight152089.9
*Water molecules are not included.

251801

PDB entries from 2026-04-08

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