7DSX
Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (D, C) | Calcineurin B homologous protein 1 | polymer | 185 | 21369.8 | 2 | UniProt (Q99653) Pfam (PF00036) | Homo sapiens (Human) | Calcineurin B-like protein,Calcium-binding protein CHP,Calcium-binding protein p22,EF-hand calcium-binding domain-containing protein p22 |
| 2 | B, D (B, A) | Sodium/hydrogen exchanger 1 | polymer | 509 | 57100.4 | 2 | UniProt (P19634) Pfam (PF00999) | Homo sapiens (Human) | APNH,Na(+)/H(+) antiporter,amiloride-sensitive,Na(+)/H(+) exchanger 1,NHE-1,Solute carrier family 9 member 1 |
| 3 | E, F, H, I, J... (B, A) | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE | non-polymer | 751.0 | 6 | Chemie (PGT) | |||
| 4 | G, L (B, A) | N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide | non-polymer | 283.3 | 2 | Chemie (HG0) |
Sequence modifications
D, C: 11 - 195 (UniProt: Q99653)
| PDB | External Database | Details |
|---|---|---|
| Ala 171 | Ile 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 156940.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 5072.8 | |
| All* | Total formula weight | 162013.2 |
