7DSN
Overall structure of the LAT1-4F2hc bound with JX-119
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 4F2 cell-surface antigen heavy chain | polymer | 647 | 70160.8 | 1 | UniProt (J3KPF3) Pfam (PF16028) Pfam (PF00128) UniProt (by SIFTS) (P08195) | Homo sapiens (Human) | 4F2hc, Solute carrier family 3 (Activators of dibasic and neutral amino acid transport),member 2,isoform CRA_a |
| 2 | B (B) | Large neutral amino acids transporter small subunit 1 | polymer | 527 | 57186.9 | 1 | UniProt (Q01650) Pfam (PF13520) | Homo sapiens (Human) | 4F2 light chain,4F2LC,CD98 light chain,Integral membrane protein E16,E16,L-type amino acid transporter 1,hLAT1,Solute carrier family 7 member 5,y+ system cationic amino acid transporter |
| 3 | C, D, E, F (C, D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | G (A) | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE | non-polymer | 705.0 | 1 | Chemie (3PH) PubChem (447938) PubChem (16211043) PubChem (86641) | |||
| 5 | H (B) | (2~{S})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl)phenyl]methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid | non-polymer | 414.5 | 1 | Chemie (HO9) PubChem (155804223) | |||
| 6 | I, J (B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 7 | K (B) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 2 - 631 (UniProt: J3KPF3)
B: 2 - 507 (UniProt: Q01650)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Ala -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Arg 1 | - | expression tag |
| Leu 632 | - | expression tag |
| Glu 633 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
| Ala -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Lys -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Lys -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Arg 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127347.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2092.9 | |
| All* | Total formula weight | 131138.2 |
