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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7DCO

Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APRP8 isoform 1polymer2413279867.51UniProt (A0A6A5PW68)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
2BU5 snRNApolymer21468643.31GenBank (1039023403)Saccharomyces cerevisiae
3CSNU114 isoform 1polymer1008114174.01UniProt (A0A6A5PW35)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
4DBRR2 isoform 1polymer2163246470.31UniProt (A0A6A5Q2I8)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
5dSmall nuclear ribonucleoprotein Sm D3polymer10111240.11UniProt (A0A6A5Q3H8)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Sm-D3,snRNP core protein D3
6a, hBJ4_G0014900.mRNA.1.CDS.1polymer19622427.02UniProt (A0A6A5Q0I3)
In PDB		Saccharomyces cerevisiae (Baker's yeast)HLJ1_G0014660.mRNA.1.CDS.1,SMB1 isoform 1,Y55_G0014800.mRNA.1.CDS.1
7b, mSMD1 isoform 1polymer14616296.82UniProt (A0A6A5Q0W7)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
8c, nBJ4_G0037700.mRNA.1.CDS.1polymer11012876.12UniProt (A0A6L0ZK95)
In PDB		Saccharomyces cerevisiae (Baker's yeast)HLJ1_G0037800.mRNA.1.CDS.1,HN1_G0037500.mRNA.1.CDS.1,Y55_G0037640.mRNA.1.CDS.1
9e, iSmall nuclear ribonucleoprotein Epolymer9410385.12UniProt (A0A6A5Q895)
In PDB		Saccharomyces cerevisiae (Baker's yeast)snRNP-E,Sm protein E
10f, jSm protein Fpolymer869669.92UniProt (A0A6A5Q5K4)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
11g, kSmall nuclear ribonucleoprotein Gpolymer778490.82UniProt (P40204)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)snRNP-G,Sm protein G,SmG
12FU6 snRNApolymer11235883.21GenBank (1039022925)Saccharomyces cerevisiae
13Gpre-mRNApolymer16244772.21Saccharomyces cerevisiae
14HU2 snRNApolymer1175376324.61Saccharomyces cerevisiae
15oHLJ1_G0053790.mRNA.1.CDS.1polymer23827232.31UniProt (A0A6A5Q2G3)
In PDB		Saccharomyces cerevisiae (Baker's yeast)LEA1 isoform 1,Y55_G0053650.mRNA.1.CDS.1
16pBJ4_G0027490.mRNA.1.CDS.1polymer11112850.91UniProt (A0A6A5Q318)
In PDB		Saccharomyces cerevisiae (Baker's yeast)HN1_G0027200.mRNA.1.CDS.1,MSL1 isoform 1,SX2_G0029270.mRNA.1.CDS.1,Y55_G0027550.mRNA.1.CDS.1
17lSmall nuclear ribonucleoprotein Sm D3polymer818882.21UniProt (A0A6A5Q3H8)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Sm-D3,snRNP core protein D3
18uPRP9 isoform 1polymer53063126.41UniProt (A0A6A5PZ67)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
19wPre-mRNA-splicing factor PRP21polymer28033111.51UniProt (P32524)
Pfam (PF12230)
Pfam (PF01805)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
20vPRP11 isoform 1polymer26629962.81UniProt (A0A6A5Q100)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
211HSH155 isoform 1polymer971110166.71UniProt (A0A6A5PSM1)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
222HLJ1_G0043010.mRNA.1.CDS.1polymer23827503.81UniProt (A0A6L0ZSI9)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
233RSE1 isoform 1polymer1361153956.81UniProt (A0A6A5PUP5)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
244HSH49 isoform 1polymer21324534.21UniProt (A0A6A5Q466)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
255BJ4_G0056610.mRNA.1.CDS.1polymer10712283.61UniProt (A0A6A5Q1K7)
In PDB		Saccharomyces cerevisiae (Baker's yeast)EM14S01-3B_G0056430.mRNA.1.CDS.1,HLJ1_G0056610.mRNA.1.CDS.1,HN1_G0056420.mRNA.1.CDS.1,JXXY16.1_G0056310.mRNA.1.CDS.1,RDS3 isoform 1,SX2_G0056170.mRNA.1.CDS.1,XXYS1_G0055940.mRNA.1.CDS.1,Y55_G0056510.mRNA.1.CDS.1
266RDS3 complex subunit 10polymer849888.21UniProt (P0C074)
Pfam (PF07189)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Splicing factor 3b subunit
27LPre-mRNA-splicing factor CEF1polymer59067837.81UniProt (Q03654)
Pfam (PF00249)
Pfam (PF11831)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)PRP nineteen-associated complex protein 85,PRP19-associated complex protein 85
28s, t, q, rPre-mRNA-processing factor 19polymer50356629.84UniProt (A0A6A5PQI0)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
29KSNT309 isoform 1polymer17520741.51UniProt (A0A6A5Q641)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Y55_G0056570.mRNA.1.CDS.1
30NBUD31 isoform 1polymer15718484.51UniProt (A0A6A5Q3N1)
In PDB		Saccharomyces cerevisiae (Baker's yeast)EM14S01-3B_G0005920.mRNA.1.CDS.1,HLJ1_G0006010.mRNA.1.CDS.1,JXXY16.1_G0005970.mRNA.1.CDS.1,Pre-mRNA-splicing factor BUD31,SX2_G0005960.mRNA.1.CDS.1,XXYS1_G0005950.mRNA.1.CDS.1,Y55_G0006020.mRNA.1.CDS.1
31THLJ1_G0054350.mRNA.1.CDS.1polymer33737639.71UniProt (A0A6L0ZMZ1)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Pre-mRNA-splicing factor PRP46
32PPre-mRNA-processing protein 45polymer37942548.71UniProt (A0A6A5PTY9)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
33QPre-mRNA-splicing factor SLT11polymer36440988.61UniProt (A0A6A5Q0Z2)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
34RPre-mRNA-splicing factor CWC2polymer26129742.81UniProt (A0A6A5Q155)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
35SPre-mRNA-splicing factor CWC15polymer17519975.21UniProt (Q03772)
Pfam (PF04889)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complexed with CEF1 protein 15
36YPre-mRNA leakage protein 1polymer20423685.71UniProt (Q07930)
Pfam (PF00498)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
37XSX2_G0027210.mRNA.1.CDS.1polymer12814880.51UniProt (A0A6L1ALU2)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
38ZPre-mRNA-splicing factor CWC26polymer12114039.61UniProt (A0A6L1AYM3)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
39WCDC40 isoform 1polymer45552128.81UniProt (A0A6A5PYD5)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
40UPre-mRNA-splicing factor CWC21polymer13515793.61UniProt (A0A6A5PZG6)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
41VCWC22 isoform 1polymer57767386.11UniProt (A0A6A5Q1E9)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
42MPre-mRNA-splicing factor CWC24polymer25929797.91UniProt (A0A6A5PVM6)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
43zCWC27 isoform 1polymer30135080.91UniProt (A0A6A5Q291)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
44yPre-mRNA-splicing factor SPP2polymer18520685.41UniProt (Q02521)
Pfam (PF12656)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Spliceosome maturation protein SPP2,Suppressor of PRP protein 2
45JCLF1 isoform 1polymer68782555.91UniProt (A0A6A5PT67)
In PDB		Saccharomyces cerevisiae (Baker's yeast)Pre-mRNA-splicing factor CLF1
46ISYF1 isoform 1polymer859100344.01UniProt (A0A6A5Q0A4)
In PDB		Saccharomyces cerevisiae (Baker's yeast)
47xPre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2polymer87699947.51UniProt (P20095)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF04408)
Pfam (PF21010)
Pfam (PF07717)
In PDB		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Pre-mRNA-processing protein 2
48AINOSITOL HEXAKISPHOSPHATEnon-polymer660.01Chemie (IHP)
49CGUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
50C, F, 3MAGNESIUM IONnon-polymer24.36Chemie (MG)
51CCALCIUM IONnon-polymer40.11Chemie (CA)
52M, u, v, 5, N...ZINC IONnon-polymer65.415Chemie (ZN)
53waterwater18.01714Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains56
Total formula weight2911969.6
Non-Polymers*Number of molecules24
Total formula weight2350.3
All*Total formula weight2914319.9
*Water molecules are not included.

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PDB entries from 2024-09-04

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