7D3F

Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Dual oxidase 1	polymer	1551	177483.8	2	UniProt (Q9NRD9) Pfam (PF03098) Pfam (PF00036) Pfam (PF13499) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030)	Homo sapiens (Human)	Large NOX 1,Long NOX 1,NADPH thyroid oxidase 1,Thyroid oxidase 1
2	B, D (B, D)	Isoform 2 of Dual oxidase maturation factor 1	polymer	483	53579.2	2	UniProt (Q1HG43) Pfam (PF10204)	Homo sapiens (Human)	Dual oxidase activator 1,Numb-interacting protein
3	E, F (E, F)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1721.5	2	In PDB GlyTouCan (G40702WU)
4	G, H, T, U (A, C)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
5	I, V (A, C)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
6	J, W (A, C)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
7	K, L, X, Y (A, C)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
8	AA, BA, EA, FA, M... (C, D, A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
9	CA, DA, P, Q (C, A)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
10	GA, HA (A, C)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, C: 1 - 1551 (UniProt: Q9NRD9)

PDB	External Database	Details
Phe 1178	Leu 1178	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	462126.0
Branched	Number of molecules	2
	Total formula weight	3443.1
Non-Polymers*	Number of molecules	26
	Total formula weight	7992.2
All*	Total formula weight	473561.3

*Water molecules are not included.