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7D3F

Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005509molecular_functioncalcium ion binding
A0006979biological_processresponse to oxidative stress
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
B0005515molecular_functionprotein binding
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0008104biological_processprotein localization
B0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0042743biological_processhydrogen peroxide metabolic process
B0045666biological_processpositive regulation of neuron differentiation
B0050727biological_processregulation of inflammatory response
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
B2000609biological_processregulation of thyroid hormone generation
C0004601molecular_functionperoxidase activity
C0005509molecular_functioncalcium ion binding
C0006979biological_processresponse to oxidative stress
C0016491molecular_functionoxidoreductase activity
C0020037molecular_functionheme binding
D0005515molecular_functionprotein binding
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0008104biological_processprotein localization
D0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0042743biological_processhydrogen peroxide metabolic process
D0045666biological_processpositive regulation of neuron differentiation
D0050727biological_processregulation of inflammatory response
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
D2000609biological_processregulation of thyroid hormone generation
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGNGYLSfrEF
ChainResidueDetails
AASP828-PHE840
AASP864-PHE876

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues308
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BMET1-LEU24
BSER73-MET183
BTHR228-PRO249
DMET1-LEU24
DSER73-MET183
DTHR228-PRO249
CHIS1172-GLN1188
CARG1248

site_idSWS_FT_FI2
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BALA25-ILE45
DALA250-VAL270
CVAL1149-PHE1171
CTHR1189-ALA1209
CLEU1227-PRO1247
CPHE1249-SER1269
BPHE52-PHE72
BLEU184-VAL204
BGLY207-ALA227
BALA250-VAL270
DALA25-ILE45
DPHE52-PHE72
DLEU184-VAL204
DGLY207-ALA227

site_idSWS_FT_FI3
Number of Residues156
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BARG46-LEU51
BTYR205-GLY206
BALA271-VAL343
DARG46-LEU51
DTYR205-GLY206
DALA271-VAL343
CSER1210-HIS1226
CARG1270-PHE1551

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN84
CASP828
CASP830
CASN832
CTYR834
CGLU839
CASP864
CASP866
CASN868
CGLU875
BASN109
BASN121
DASN84
DASN109
DASN121
AASP866
AASN868
AGLU875

site_idSWS_FT_FI5
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN94
CASN534
AASN342
AASN354
AASN461
AASN534
CASN94
CASN342
CASN354
CASN461

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PDB entries from 2025-06-18

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