7D3F

Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005509	molecular_function	calcium ion binding
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0008104	biological_process	intracellular protein localization
B	0010729	biological_process	positive regulation of hydrogen peroxide biosynthetic process
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0042743	biological_process	hydrogen peroxide metabolic process
B	0045666	biological_process	positive regulation of neuron differentiation
B	0050727	biological_process	regulation of inflammatory response
B	0072659	biological_process	protein localization to plasma membrane
B	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
B	2000609	biological_process	regulation of thyroid hormone generation
C	0004601	molecular_function	peroxidase activity
C	0005509	molecular_function	calcium ion binding
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
D	0005515	molecular_function	protein binding
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0008104	biological_process	intracellular protein localization
D	0010729	biological_process	positive regulation of hydrogen peroxide biosynthetic process
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0042743	biological_process	hydrogen peroxide metabolic process
D	0045666	biological_process	positive regulation of neuron differentiation
D	0050727	biological_process	regulation of inflammatory response
D	0072659	biological_process	protein localization to plasma membrane
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
D	2000609	biological_process	regulation of thyroid hormone generation

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGNGYLSfrEF

Chain	Residue	Details
A	ASP828-PHE840
A	ASP864-PHE876

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1472
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

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site_id	SWS_FT_FI2
Number of Residues	484
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	136
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	364
Details	Domain: {"description":"Ferric oxidoreductase"}

Chain

Residue

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site_id	SWS_FT_FI6
Number of Residues	1134
Details	Region: {"description":"Peroxidase-like; mediates peroxidase activity"}

Chain

Residue

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site_id	SWS_FT_FI7
Number of Residues	44
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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