7C7I
Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ras-related protein Rap-1b | polymer | 167 | 19006.4 | 2 | UniProt (P61224) Pfam (PF00071) | Homo sapiens (Human) | GTP-binding protein smg p21B |
| 2 | C, D (C, D) | SH3 and multiple ankyrin repeat domains protein 3 | polymer | 99 | 11193.9 | 2 | UniProt (Q9BYB0) | Homo sapiens (Human) | Shank3,Proline-rich synapse-associated protein 2,ProSAP2 |
| 3 | E, H (A, B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 4 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | G, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 167 (UniProt: P61224)
| PDB | External Database | Details |
|---|---|---|
| Asp 30 | Glu 30 | engineered mutation |
| Glu 31 | Lys 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60400.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1135.0 | |
| All* | Total formula weight | 61535.6 |
