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7C7I

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0008283biological_processcell population proliferation
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017156biological_processcalcium-ion regulated exocytosis
A0019003molecular_functionGDP binding
A0030033biological_processmicrovillus assembly
A0032486biological_processRap protein signal transduction
A0033625biological_processpositive regulation of integrin activation
A0035577cellular_componentazurophil granule membrane
A0044877molecular_functionprotein-containing complex binding
A0045121cellular_componentmembrane raft
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0051649biological_processestablishment of localization in cell
A0061028biological_processestablishment of endothelial barrier
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071320biological_processcellular response to cAMP
A0098978cellular_componentglutamatergic synapse
A0099010biological_processmodification of postsynaptic structure
A1901888biological_processregulation of cell junction assembly
A2000114biological_processregulation of establishment of cell polarity
A2000301biological_processnegative regulation of synaptic vesicle exocytosis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017156biological_processcalcium-ion regulated exocytosis
B0019003molecular_functionGDP binding
B0030033biological_processmicrovillus assembly
B0032486biological_processRap protein signal transduction
B0033625biological_processpositive regulation of integrin activation
B0035577cellular_componentazurophil granule membrane
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0045955biological_processnegative regulation of calcium ion-dependent exocytosis
B0051649biological_processestablishment of localization in cell
B0061028biological_processestablishment of endothelial barrier
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071320biological_processcellular response to cAMP
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B1901888biological_processregulation of cell junction assembly
B2000114biological_processregulation of establishment of cell polarity
B2000301biological_processnegative regulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues27
Detailsbinding site for residue GTP A 201
ChainResidue
AGLY12
AASP30
AGLU31
ATYR32
AASP33
ATHR35
AASP57
ATHR58
AASN116
ALYS117
AASP119
AGLY13
ALEU120
ASER147
AALA148
ALYS149
AMG203
AHOH303
AHOH316
AHOH325
AVAL14
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 202
ChainResidue
AASN155
AGLU156
AHOH337
BASN155
BGLU156
BHOH332

site_idAC3
Number of Residues5
Detailsbinding site for residue MG A 203
ChainResidue
ASER17
ATYR32
AASP33
ATHR35
AGTP201

site_idAC4
Number of Residues26
Detailsbinding site for residue GTP B 201
ChainResidue
BGLY12
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BVAL29
BASP30
BGLU31
BTYR32
BASP33
BTHR35
BASP57
BTHR58
BASN116
BLYS117
BASP119
BLEU120
BSER147
BALA148
BLYS149
BMG202
BHOH317
BHOH326

site_idAC5
Number of Residues5
Detailsbinding site for residue MG B 202
ChainResidue
BSER17
BASP33
BTHR35
BGTP201
BHOH317

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140
ChainResidueDetails
AGLY10
AASP57
AASN116
ASER147
BGLY10
BASP57
BASN116
BSER147

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: ADP-ribosylserine; by botulinum toxin => ECO:0000305|PubMed:3141412
ChainResidueDetails
ASER39
BSER39

226707

PDB entries from 2024-10-30

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