7C60

Crystal structure of Keap1 in complex with monoethyl fumarate (MEF)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Kelch-like ECH-associated protein 1	polymer	310	34113.1	1	UniProt (Q9Z2X8) Pfam (PF01344)	Mus musculus (Mouse)	Cytosolic inhibitor of Nrf2,INrf2
2	B, D (A)	(~{Z})-4-ethoxy-4-oxidanylidene-but-2-enoic acid	non-polymer		144.1	2	Chemie (NF3)
3	C (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
4	E, F (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	G (A)	water	water		18.0	491	Chemie (HOH)

Sequence modifications

A: 324 - 616 (UniProt: Q9Z2X8)

PDB	External Database	Details
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
Ser 313	-	expression tag
Ser 314	-	expression tag
Gly 315	-	expression tag
Leu 316	-	expression tag
Val 317	-	expression tag
Pro 318	-	expression tag
Arg 319	-	expression tag
Gly 320	-	expression tag
Ser 321	-	expression tag
His 322	-	expression tag
Met 323	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34113.1
Non-Polymers*	Number of molecules	5
	Total formula weight	539.4
All*	Total formula weight	34652.5

*Water molecules are not included.