7C44
Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | Protein Mdm4 | polymer | 96 | 11042.8 | 1 | UniProt (O15151) | Homo sapiens (Human) | Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4 |
2 | B (A) | 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one | non-polymer | 581.5 | 1 | Chemie (NUT) | |||
3 | C (A) | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | non-polymer | 264.3 | 1 | Chemie (O4B) | |||
4 | D (A) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 22 - 107 (UniProt: O15151)
PDB | External Database | Details |
---|---|---|
Asp 12 | - | expression tag |
Leu 13 | - | expression tag |
Glu 14 | - | expression tag |
Asn 15 | - | expression tag |
Leu 16 | - | expression tag |
Tyr 17 | - | expression tag |
Phe 18 | - | expression tag |
Gln 19 | - | expression tag |
Gly 20 | - | expression tag |
Ser 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 11042.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 845.8 | |
All* | Total formula weight | 11888.6 |