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7C44

Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Protein Mdm4polymer9611042.81UniProt (O15151)Homo sapiens (Human)Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4
2B
(A)
4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-onenon-polymer581.51Chemie (NUT)
3C
(A)
1,4,7,10,13,16-HEXAOXACYCLOOCTADECANEnon-polymer264.31Chemie (O4B)
4D
(A)
waterwater18.026Chemie (HOH)
Sequence modifications
A: 22 - 107 (UniProt: O15151)
PDBExternal DatabaseDetails
Asp 12-expression tag
Leu 13-expression tag
Glu 14-expression tag
Asn 15-expression tag
Leu 16-expression tag
Tyr 17-expression tag
Phe 18-expression tag
Gln 19-expression tag
Gly 20-expression tag
Ser 21-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight11042.8
Non-Polymers*Number of molecules2
Total formula weight845.8
All*Total formula weight11888.6
*Water molecules are not included.

227344

PDB entries from 2024-11-13

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