7BTS
Structure of human beta1 adrenergic receptor bound to epinephrine and nanobody 6B9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysozyme-Beta-1 adrenergic receptor chimera | polymer | 462 | 52235.9 | 1 | UniProt (D9IEF7) Pfam (PF00959) Pfam (PF00001) UniProt (by SIFTS) (P08588) | Enterobacteria phage T4 | Lysis protein,Lysozyme,Muramidase |
| 2 | B (B) | Camelid Antibody Fragment | polymer | 120 | 12949.4 | 1 | Vicugna pacos (Alpaca) | ||
| 3 | C (A) | L-EPINEPHRINE | non-polymer | 183.2 | 1 | Chemie (ALE) | |||
| 4 | D, E, F, G, H... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | J (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | K (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 7 | L (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 8 | M (A) | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate | non-polymer | 300.4 | 1 | Chemie (1WV) |
Sequence modifications
A: 892 - 1051 (UniProt: D9IEF7)
A: 1054 - 1399 (PDB: 7BTS)
| PDB | External Database | Details |
|---|---|---|
| Asp 884 | - | expression tag |
| Tyr 885 | - | expression tag |
| Lys 886 | - | expression tag |
| Asp 887 | - | expression tag |
| Asp 888 | - | expression tag |
| Asp 889 | - | expression tag |
| Asp 890 | - | expression tag |
| Ala 891 | - | expression tag |
| Thr 944 | Cys 54 | engineered mutation |
| Ala 987 | Cys 97 | engineered mutation |
| Ala 1052 | - | linker |
| Ala 1053 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65185.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1708.0 | |
| All* | Total formula weight | 66893.2 |
