7BI9
PI3KC2a core in complex with PIK90
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | polymer | 910 | 102486.0 | 1 | UniProt (Q61194) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Mus musculus (House mouse) | PtdIns-3-kinase C2 subunit alpha,Cpk-m,Phosphoinositide 3-kinase-C2-alpha,p170,PtdIns-3-kinase C2 subunit alpha,Cpk-m,Phosphoinositide 3-kinase-C2-alpha,p170 |
| 2 | B (A) | N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE | non-polymer | 350.4 | 1 | Chemie (090) | |||
| 3 | C, D, E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | H (A) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A: 3 - 266 (UniProt: Q61194)
A: 284 - 1018 (UniProt: Q61194)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 267 | - | linker |
| Ser 268 | - | linker |
| Gly 269 | - | linker |
| Ser 270 | - | linker |
| Val 271 | - | linker |
| Met 272 | - | linker |
| Thr 273 | - | linker |
| Arg 274 | - | linker |
| His 275 | - | linker |
| Ser 276 | - | linker |
| Ala 277 | - | linker |
| Gly 278 | - | linker |
| Ala 279 | - | linker |
| Gly 280 | - | linker |
| Ser 281 | - | linker |
| Gly 282 | - | linker |
| Ala 283 | - | linker |
| Gly 286 | Ala 668 | conflict |
| Ala 353 | Phe 735 | engineered mutation |
| Ala 354 | Phe 736 | engineered mutation |
| Ala 427 | Leu 809 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 102486.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 660.7 | |
| All* | Total formula weight | 103146.7 |
