7BI9

PI3KC2a core in complex with PIK90

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016301	molecular_function	kinase activity
A	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 090 A 1101

Chain	Residue
A	LYS756
A	ASP764
A	PHE790
A	GLU803
A	VAL805
A	SER808
A	MET875
A	ILE885
A	ASP886

---

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 1102

Chain	Residue
A	ASP634
A	ARG762

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 1103

Chain	Residue
A	LEU558
A	GLU588
A	LYS780

---

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 1104

Chain	Residue
A	GLN4
A	LYS922

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 1105

Chain	Residue
A	LEU420
A	THR421
A	CYS422
A	PRO459
A	PRO461

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 1106

Chain	Residue
A	PHE66
A	THR67
A	TRP84
A	GLN303
A	ILE364

---

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKvg.EDLRQDmlalQ

Chain	Residue	Details
A	PHE755-GLN769

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgccVatYVLgIcDRHndN

Chain	Residue	Details
A	SER853-ASN873

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---