7BBJ
CD73 in complex with the humanized antagonistic antibody mAb19
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 5'-nucleotidase | polymer | 546 | 60464.3 | 2 | UniProt (P21589) Pfam (PF00149) Pfam (PF02872) In PDB | Homo sapiens (Human) | 5'-NT,Ecto-5'-nucleotidase |
2 | H, M | heavy chain mAb19 | polymer | 222 | 23945.0 | 2 | synthetic construct | ||
3 | L, N | light chain mAB19 | polymer | 214 | 23647.3 | 2 | synthetic construct | ||
4 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
5 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 549 (UniProt: P21589)
PDB | External Database | Details |
---|---|---|
Met 4 | - | initiating methionine |
Ala 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
His 8 | - | expression tag |
His 9 | - | expression tag |
His 10 | - | expression tag |
His 11 | - | expression tag |
Val 12 | - | expression tag |
Gly 13 | - | expression tag |
Thr 14 | - | expression tag |
Gly 15 | - | expression tag |
Ser 16 | - | expression tag |
Asn 17 | - | expression tag |
Asp 18 | - | expression tag |
Asp 19 | - | expression tag |
Asp 20 | - | expression tag |
Asp 21 | - | expression tag |
Lys 22 | - | expression tag |
Ser 23 | - | expression tag |
Pro 24 | - | expression tag |
Asp 25 | - | expression tag |
Pro 26 | - | expression tag |
Asp 53 | Asn 53 | engineered mutation |
Ser 145 | Lys 145 | engineered mutation |
Ser 147 | Lys 147 | engineered mutation |
Asp 311 | Asn 311 | engineered mutation |
Asp 333 | Asn 333 | engineered mutation |
Ala 376 | Thr 376 | conflict |
Asp 403 | Asn 403 | engineered mutation |
Ser 478 | Lys 478 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 216113.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 310.2 | |
All* | Total formula weight | 216423.6 |