7B26

CirpA1 in complex with pseudo-monomeric Properdin lacking TSR2-3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Properdin	polymer	247	27484.5	1	UniProt (P27918) Pfam (PF00090) Pfam (PF22195) In PDB	Homo sapiens (Human)	Complement factor P
2	A	Properdin	polymer	134	14485.6	1	UniProt (P27918) Pfam (PF18487) Pfam (PF00090) In PDB	Homo sapiens (Human)	Complement factor P;FP head fragment (TB-TSR1)
3	C	CirpA1	polymer	180	20431.5	1		Rhipicephalus pulchellus
4	D	beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose	branched		326.3	1	In PDB GlyTouCan (G36855WW)
5	B, A	alpha-D-mannopyranose	non-polymer		180.2	8	Chemie (MAN)
6	B	beta-D-mannopyranose	non-polymer		180.2	1	Chemie (BMA)

Sequence modifications

B: 256 - 469 (UniProt: P27918)

PDB	External Database	Details
Met 229	-	initiating methionine
Ile 230	-	expression tag
Thr 231	-	expression tag
Glu 232	-	expression tag
Gly 233	-	expression tag
Ala 234	-	expression tag
Gln 235	-	expression tag
Ala 236	-	expression tag
Pro 237	-	expression tag
Arg 238	-	expression tag
Leu 239	-	expression tag
Leu 240	-	expression tag
Leu 241	-	expression tag
Pro 242	-	expression tag
Pro 243	-	expression tag
Leu 244	-	expression tag
Leu 245	-	expression tag
Leu 246	-	expression tag
Leu 247	-	expression tag
Leu 248	-	expression tag
Thr 249	-	expression tag
Leu 250	-	expression tag
Pro 251	-	expression tag
Ala 252	-	expression tag
Thr 253	-	expression tag
Gly 254	-	expression tag
Ser 255	-	expression tag
His 470	-	expression tag
His 471	-	expression tag
His 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag

A: 1 - 134 (UniProt: P27918)

PDB	External Database	Details
Ala 132	Cys 132	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	62401.6
Branched	Number of molecules	1
	Total formula weight	326.3
Non-Polymers*	Number of molecules	9
	Total formula weight	1621.4
All*	Total formula weight	64349.3

*Water molecules are not included.