7AKK
Structure of a complement factor-receptor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, C) | Complement C3 beta chain | polymer | 645 | 71393.3 | 2 | UniProt (P01024) Pfam (PF17789) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) | Homo sapiens (Human) | |
| 2 | B, E (A, E) | Complement C3b alpha' chain | polymer | 898 | 102064.8 | 2 | UniProt (P01024) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) Pfam (PF07677) Pfam (PF01759) | Homo sapiens (Human) | |
| 3 | C, F (D, H) | Integrin alpha-M | polymer | 195 | 22221.3 | 2 | UniProt (P11215) Pfam (PF00092) | Homo sapiens (Human) | CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor |
| 4 | G (I) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 5 | H (J) | beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G26644CA) | |||
| 6 | I, L, O (B, C, E) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | J, M (A, C) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 8 | K, P (D, H) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 9 | N (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 10 | Q, R, S, T, U (B, A, D, C, E) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A, E: 646 - 1543 (UniProt: P01024)
D, H: 127 - 321 (UniProt: P11215)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 1303 | deletion |
| - | Ser 1304 | deletion |
| - | Ser 1305 | deletion |
| - | Lys 1306 | deletion |
| - | Ile 1307 | deletion |
| - | Thr 1308 | deletion |
| - | His 1309 | deletion |
| - | Arg 1310 | deletion |
| - | Ile 1311 | deletion |
| - | His 1312 | deletion |
| - | Trp 1313 | deletion |
| - | Glu 1314 | deletion |
| - | Ser 1315 | deletion |
| - | Ala 1316 | deletion |
| - | Ser 1317 | deletion |
| - | Leu 1318 | deletion |
| - | Leu 1319 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ser 128 | Cys 144 | engineered mutation |
| Gly 316 | Ile 332 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 391358.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1335.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 624.3 | |
| All* | Total formula weight | 393318.4 |
