7AHJ
Crystal structure of PPARgamma V290M mutant ligand binding domain in complex with farglitazar
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 275 | 31424.5 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | C (A) | 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID | non-polymer | 546.6 | 1 | Chemie (570) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
A, B: 204 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | - | expression tag |
| Met 290 | Val 318 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62849.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 546.6 | |
| All* | Total formula weight | 63395.7 |
