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7AAK

Human porphobilinogen deaminase R173W mutant crystallized in the ES2 intermediate state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Porphobilinogen deaminasepolymer36339556.22UniProt (P08397)
Pfam (PF01379)
Pfam (PF03900)
Homo sapiens (Human)PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase
2C, F
(A, B)
3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acidnon-polymer838.82Chemie (7J8)
3D, E, G, H
(A, B)
GLYCEROLnon-polymer92.14Chemie (GOL)
4I, J
(A, B)
waterwater18.0505Chemie (HOH)
Sequence modifications
A, B: 1 - 361 (UniProt: P08397)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
Trp 173Arg 173engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight79112.3
Non-Polymers*Number of molecules6
Total formula weight2046.0
All*Total formula weight81158.3
*Water molecules are not included.

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PDB entries from 2025-07-09

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