7AAK
Human porphobilinogen deaminase R173W mutant crystallized in the ES2 intermediate state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Porphobilinogen deaminase | polymer | 363 | 39556.2 | 2 | UniProt (P08397) Pfam (PF01379) Pfam (PF03900) In PDB | Homo sapiens (Human) | PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase |
| 2 | A, B | 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid | non-polymer | 838.8 | 2 | Chemie (7J8) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 505 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 361 (UniProt: P08397)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Trp 173 | Arg 173 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79112.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2046.0 | |
| All* | Total formula weight | 81158.3 |
