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7AAK

Human porphobilinogen deaminase R173W mutant crystallized in the ES2 intermediate state

Functional Information from GO Data
ChainGOidnamespacecontents
A0004418molecular_functionhydroxymethylbilane synthase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006779biological_processporphyrin-containing compound biosynthetic process
A0006782biological_processprotoporphyrinogen IX biosynthetic process
A0006783biological_processheme biosynthetic process
A0006784biological_processheme A biosynthetic process
A0006785biological_processheme B biosynthetic process
A0016740molecular_functiontransferase activity
A0018160biological_processpeptidyl-pyrromethane cofactor linkage
A0033014biological_processtetrapyrrole biosynthetic process
A0048034biological_processheme O biosynthetic process
B0004418molecular_functionhydroxymethylbilane synthase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006779biological_processporphyrin-containing compound biosynthetic process
B0006782biological_processprotoporphyrinogen IX biosynthetic process
B0006783biological_processheme biosynthetic process
B0006784biological_processheme A biosynthetic process
B0006785biological_processheme B biosynthetic process
B0016740molecular_functiontransferase activity
B0018160biological_processpeptidyl-pyrromethane cofactor linkage
B0033014biological_processtetrapyrrole biosynthetic process
B0048034biological_processheme O biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00533
Number of Residues17
DetailsPORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA
ChainResidueDetails
AGLU250-ALA266

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P22907","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"S-(dipyrrolylmethanemethyl)cysteine","evidences":[{"source":"PubMed","id":"18936296","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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