6ZO7
3-Formylrifamycin SV binding to the access pocket of AcrB-G619P L and T protomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114776.4 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli K-12 | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
| 3 | BA, F, G, H, IA... (C, A, B) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 10 | Chemie (LMT) | |||
| 4 | I (A) | DECANE | non-polymer | 142.3 | 1 | Chemie (D10) | |||
| 5 | FA, J, JA, L, M... (C, A, E, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 6 | N, V (A, B) | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate | non-polymer | 725.8 | 2 | Chemie (3YI) | |||
| 7 | GA, LA, R (C, E, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | S (B) | HEXANE | non-polymer | 86.2 | 1 | Chemie (HEX) | |||
| 9 | W (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 10 | CA, X (C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 2 | Chemie (PTY) | |||
| 11 | AA, Z (C) | DODECANE | non-polymer | 170.3 | 2 | Chemie (D12) | |||
| 12 | DA (C) | HEXADECANE | non-polymer | 226.4 | 1 | Chemie (R16) | |||
| 13 | EA (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 14 | HA (C) | DECYLAMINE-N,N-DIMETHYL-N-OXIDE | non-polymer | 201.3 | 1 | Chemie (DDQ) | |||
| 15 | KA (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 16 | NA, OA, PA, QA, RA (A, B, C, D, E) | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Pro 619 | Gly 619 | conflict |
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 380964.2 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 9950.0 | |
| All* | Total formula weight | 390914.2 |
