6ZO7
3-Formylrifamycin SV binding to the access pocket of AcrB-G619P L and T protomer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1201 |
| Chain | Residue |
| A | GLY440 |
| A | MET447 |
| A | ALA890 |
| A | LEU891 |
| C | ARG8 |
| C | PHE11 |
| C | ILE18 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 1202 |
| Chain | Residue |
| A | HOH1334 |
| A | LEU28 |
| A | HIS338 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue LMT A 1203 |
| Chain | Residue |
| A | SER530 |
| A | ARG536 |
| A | SER537 |
| A | ARG540 |
| A | TYR541 |
| A | PHE1020 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue D10 A 1204 |
| Chain | Residue |
| A | TRP895 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1205 |
| Chain | Residue |
| A | ASP761 |
| A | VAL768 |
| A | LYS770 |
| B | GLN67 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1206 |
| Chain | Residue |
| A | TYR467 |
| A | PHE556 |
| A | PHE563 |
| A | ASN871 |
| A | TYR877 |
| A | ASN923 |
| A | GLN928 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1207 |
| Chain | Residue |
| A | ASN231 |
| A | SER233 |
| B | SER84 |
| B | THR724 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1208 |
| Chain | Residue |
| A | GLN124 |
| A | TYR758 |
| A | VAL759 |
| A | ASN760 |
| A | ASP761 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue 3YI A 1209 |
| Chain | Residue |
| A | MET575 |
| A | PHE617 |
| A | ARG620 |
| A | PHE664 |
| A | PHE666 |
| A | ARG717 |
| A | ASN719 |
| A | ARG815 |
| A | LEU828 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue LMT A 1210 |
| Chain | Residue |
| A | ARG8 |
| B | GLY440 |
| B | MET447 |
| B | CYS887 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1211 |
| Chain | Residue |
| A | ASN74 |
| C | THR295 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue LMT B 1201 |
| Chain | Residue |
| B | SER530 |
| B | ARG536 |
| B | ARG540 |
| B | TYR541 |
| D | ASP72 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 1202 |
| Chain | Residue |
| B | GLN124 |
| B | ARG239 |
| B | ASP761 |
| C | GLN120 |
| C | GLU121 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue LMT B 1204 |
| Chain | Residue |
| B | LYS510 |
| B | GLY511 |
| B | PHE512 |
| B | TRP515 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1205 |
| Chain | Residue |
| B | THR528 |
| B | ARG969 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue 3YI B 1206 |
| Chain | Residue |
| B | MET573 |
| B | MET575 |
| B | PHE617 |
| B | ARG620 |
| B | LEU668 |
| B | PRO669 |
| B | VAL672 |
| B | ARG717 |
| B | PRO718 |
| B | ASN719 |
| B | GLY720 |
| B | ARG815 |
| B | LEU828 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1207 |
| Chain | Residue |
| B | ASN361 |
| B | PHE362 |
| B | ARG363 |
| B | LYS498 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue PTY C 1101 |
| Chain | Residue |
| B | MET20 |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | LYS950 |
| C | SER1034 |
| C | HOH1212 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue LMT C 1102 |
| Chain | Residue |
| C | SER530 |
| C | GLY533 |
| C | ARG536 |
| C | SER537 |
| C | ARG540 |
| C | TYR541 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue LMT C 1105 |
| Chain | Residue |
| C | LYS342 |
| C | ILE991 |
| C | SER992 |
| C | THR993 |
| C | GLY994 |
| C | GLU339 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue PTY C 1106 |
| Chain | Residue |
| B | ARG8 |
| B | PHE11 |
| C | GLN439 |
| C | ALA890 |
| C | LEU891 |
| C | TYR892 |
| C | LYS950 |
| C | ASP954 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue R16 C 1107 |
| Chain | Residue |
| C | PHE458 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 1109 |
| Chain | Residue |
| C | ASP153 |
| C | ASP156 |
| C | ARG765 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 1110 |
| Chain | Residue |
| A | GLY51 |
| A | GLY755 |
| A | MET774 |
| C | GLY221 |
| C | THR222 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue DDQ C 1111 |
| Chain | Residue |
| C | ARG468 |
| C | SER471 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue LMT C 1112 |
| Chain | Residue |
| C | GLY511 |
| C | TRP515 |
| C | ARG518 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 1113 |
| Chain | Residue |
| C | TRP187 |
| C | GLU776 |
| C | ALA777 |
| C | HOH1247 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue NA C 1114 |
| Chain | Residue |
| C | PHE358 |
| C | GLN360 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 201 |
| Chain | Residue |
| A | TYR811 |
| E | GLU20 |
| E | ARG23 |
| E | ASP44 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO E 202 |
| Chain | Residue |
| E | ASP143 |
| E | LYS147 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 462 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| A | MET1-PRO9 | |
| B | GLU414-ILE438 | |
| B | ALA491-THR538 | |
| B | ALA889-PRO898 | |
| B | LEU944-LEU972 | |
| B | ILE1019-HIS1049 | |
| C | MET1-PRO9 | |
| C | LEU357-THR365 | |
| C | GLU414-ILE438 | |
| C | ALA491-THR538 | |
| C | ALA889-PRO898 | |
| A | LEU357-THR365 | |
| C | LEU944-LEU972 | |
| C | ILE1019-HIS1049 | |
| A | GLU414-ILE438 | |
| A | ALA491-THR538 | |
| A | ALA889-PRO898 | |
| A | LEU944-LEU972 | |
| A | ILE1019-HIS1049 | |
| B | MET1-PRO9 | |
| B | LEU357-THR365 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| A | ILE10-LEU28 | |
| B | ILE10-LEU28 | |
| C | ILE10-LEU28 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| A | LYS29-SER336 | |
| B | PHE556-ASN871 | |
| B | ARG919-ASP924 | |
| B | THR993-GLY998 | |
| C | LYS29-SER336 | |
| C | PHE386-ASN391 | |
| C | PHE458-ALA465 | |
| C | PHE556-ASN871 | |
| C | ARG919-ASP924 | |
| C | THR993-GLY998 | |
| A | PHE386-ASN391 | |
| A | PHE458-ALA465 | |
| A | PHE556-ASN871 | |
| A | ARG919-ASP924 | |
| A | THR993-GLY998 | |
| B | LYS29-SER336 | |
| B | PHE386-ASN391 | |
| B | PHE458-ALA465 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | ILE337-TYR356 | |
| B | ILE337-TYR356 | |
| C | ILE337-TYR356 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | LEU366-ALA385 | |
| B | LEU366-ALA385 | |
| C | LEU366-ALA385 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | THR392-VAL413 | |
| B | THR392-VAL413 | |
| C | THR392-VAL413 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | GLN439-ALA457 | |
| B | GLN439-ALA457 | |
| C | GLN439-ALA457 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | ILE466-PRO490 | |
| B | ILE466-PRO490 | |
| C | ILE466-PRO490 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | GLY539-LEU555 | |
| B | GLY539-LEU555 | |
| C | GLY539-LEU555 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=8 |
| Chain | Residue | Details |
| A | GLN872-LEU888 | |
| B | GLN872-LEU888 | |
| C | GLN872-LEU888 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=9 |
| Chain | Residue | Details |
| A | PHE899-PHE918 | |
| B | PHE899-PHE918 | |
| C | PHE899-PHE918 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=10 |
| Chain | Residue | Details |
| A | VAL925-ILE943 | |
| B | VAL925-ILE943 | |
| C | VAL925-ILE943 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=11 |
| Chain | Residue | Details |
| A | ARG973-SER992 | |
| B | ARG973-SER992 | |
| C | ARG973-SER992 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | TRANSMEM: Helical; Name=12 |
| Chain | Residue | Details |
| A | ALA999-ALA1018 | |
| B | ALA999-ALA1018 | |
| C | ALA999-ALA1018 |
